Validity and Reliability of Neurological Scores in Mice Exposed to Middle Cerebral Artery Occlusion
Validity and Reliability of Neurological Scores in Mice Exposed to Middle Cerebral Artery Occlusion
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DOI：
10.1161/strokeaha.119.026652
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发表时间：
2019-10-01
期刊：
影响因子：
8.3
通讯作者：
Hermann, Dirk M.
中科院分区：
文献类型：
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作者：
Bieber, Michael;Gronewold, Janine;Hermann, Dirk M.
背景和目的-选择合适的神经学评分和测试对卒中后果的评估至关重要。神经功能缺损评分和测试的有效性和可靠性在过去的缺血性中风模型中一再受到质疑。方法-在198只短暂性大脑中动脉闭塞的雄性小鼠中，我们检查了11种神经功能评分的有效性和可靠性（Bederson评分0-3、Bederson评分0-4、Bederson评分0-5、改良神经系统严重程度[0-14]、主观总体印象[0-10]或简单神经系统检查：抓握试验、移动体长潜伏期试验、杆试验、钢丝悬挂试验、负趋地性试验和升高身体摆动试验）。结果脑梗死体积左偏（中位数[Q1-Q3]，78.4 [54.8-101.3] mm（3））。在所有检验中，Bederson（0-5; r=0.63，P
Background and Purpose-The selection of appropriate neurological scores and tests is crucial for the evaluation of stroke consequences. The validity and reliability of neurological deficit scores and tests has repeatedly been questioned in ischemic stroke models in the past.Methods-In 198 male mice exposed to transient intraluminal middle cerebral artery occlusion, we examined the validity and reliability of 11 neurological scores (Bederson score 0-3, Bederson score 0-4, Bederson score 0-5, modified neurological severity [0-14], subjective overall impression [0-10], or simple neurological tests: grip test, latency to move body length test, pole test, wire hanging test, negative geotaxis test, and elevated body swing test) in the acute stroke phase, that is, after 24 hours. Combinations of neurological scores or tests for predicting infarct volume were statistically analyzed.Results-Infarct volume was left skewed (median [Q1-Q3], 78.4 [54.8-101.3] mm(3)). Among all tests, the Bederson (0-5; r=0.63, P