Telomerase activity in ordinary meningiomas predicts poor outcome
Telomerase activity in ordinary meningiomas predicts poor outcome
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DOI：
10.1016/s0046-8177(97)90029-0
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发表时间：
1997-04-01
期刊：
影响因子：
3.3
通讯作者：
Shay, JW
中科院分区：
文献类型：
--
作者：
Langford, LA;Piatyszek, MA;Shay, JW
端粒酶是一种稳定端粒长度的酶，几乎在所有类型的癌症中都会重新激活，它可能是细胞无限增殖所必需的。对普通脑膜瘤的恶性程度的评估是不确定的，因为侵袭性的临床行为和组织学特征或核型异常之间没有明确的相关性。我们用高灵敏的端粒重复序列扩增方法分析了52例脑膜瘤的端粒酶活性，并比较了端粒酶阳性和阴性的普通脑膜瘤的临床表现。52个肿瘤中有26个(50%)具有可检测到的端粒酶活性。在被归类为恶性或不典型的22个肿瘤中，有21个(95%)具有可检测到的端粒酶活性，这些肿瘤通常预后较差。有趣的是，30个普通(形态良性)脑膜瘤中有5个(17%)也显示出端粒酶活性。在5例端粒酶阳性的普通脑膜瘤患者中，3例在大体全切除后肿瘤迅速再生长。其余2例患者还伴有其他原发恶性肿瘤。我们观察到，在普通脑膜瘤中，端粒酶活性的存在与患者预后不良之间存在高度显著的相关性(P=.0002)。良性脑膜瘤的端粒酶活性具有临床意义，因为该酶的存在提示这些良性肿瘤可能含有永生细胞群。端粒酶活性的检测可能有助于识别良性脑膜瘤，如果手术切除不彻底，这些脑膜瘤在临床上更有可能继续生长和复发。版权所有(C)1997，由W.B.Saunders公司提供。
Telomerase, the enzyme that stabilizes telomere length, is reactivated with almost all cancer types, and it may be necessary for unlimited cell proliferation. Assessment of malignancy in ordinary meningiomas is inconclusive because no clear-cut correlation exists between aggressive clinical behavior and histological features or karyotypic abnormalities. We analyzed telomerase activity in 52 cases of meningioma by using the highly sensitive telomeric repeat amplification protocol and then compared clinical behavior in telomerase-positive and -negative ordinary meningiomas. Twenty-six of the 52 tumors (50%) had detectable telomerase activity. Twenty-one of the 22 neoplasms classified as malignant or atypical (95%) had detectable telomerase activity, and these tumors generally had a poor outcome. Interestingly, 5 of 30 ordinary (morphologically benign) meningiomas (17%) also showed detectable telomerase activity. Of the 5 patients with telomerase-positive ordinary meningiomas, 3 had rapid regrowth of the tumor despite gross total resection. The remaining 2 patients also had other primary malignancies. We observed a highly significant correlation in ordinary meningiomas between the presence of telomerase activity and a poor prognosis for the patient (P =.0002). Telomerase activity in benign meningiomas is clinically relevant because the presence of the enzyme suggests that these benign-appearing tumors may contain a population of immortal cells. The detection of telomerase activity may help to identify benign meningiomas that would be more likely to continue to grow and to recur clinically if surgical resection were incomplete. Copyright (C) 1997 by W.B. Saunders Company.