Prototype device for endoventricular beta-emitting radiotracer detection and molecularly-guided intervention.
Prototype device for endoventricular beta-emitting radiotracer detection and molecularly-guided intervention.
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DOI：
10.1007/s12350-020-02317-8
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Sinusas AJ
中科院分区：
文献类型：
--
作者：
Stendahl JC;Liu Z;Boutagy NE;Nataneli E;Daghighian F;Sinusas AJ
我们已经着手开发一种基于导管的治疗系统，该系统：a)通过心内膜检测系统发射的β放射示踪剂来识别病变和高危心肌，以及b)利用分子信号通过直接心肌内注射将治疗药物输送到适当的组织。我们的原型设备由一个包含在柔性血管内导管末端的微型β辐射探测器组成。该导管可适用于结合注射端口和用于治疗输送的可伸缩针头。在心肌梗死后1周全身注射18F-脱氧葡萄糖(18F-β)后，用不同的放射性核素对β检测导管的性能进行了体外和体外实验。将基于导管的局部心内膜18F活度测量结果与PET/CT图像和伽马计数的局部组织活度进行比较。该β检测导管对22Na(β+)、18F(β+)和204Tl(β+)的β−辐射具有较高的检测灵敏度，对γ辐射的灵敏度最低。对于18F，该导管的接触灵敏度为4,067次/S/μCi，空间分辨率为1.1 mm半高宽。用β检测导管对猪慢性心肌梗死模型的体外心内膜~(18)F活度进行了测量，结果表明，18F活度与心肌局部组织活度有很好的定性和定量相关性。原型β检测导管在广泛的能量范围内展示了对β−和β+排放的灵敏和选择性检测，并能够高保真地从系统输送的18F-FDG体外表征心内膜活动。
We have set out to develop a catheter-based theranostic system that: a) identifies diseased and at-risk myocardium via endocardial detection of systemically delivered β-emitting radiotracers and b) utilizes molecular signals to guide delivery of therapeutics to appropriate tissue via direct intramyocardial injection. Our prototype device consists of a miniature β-radiation detector contained within the tip of a flexible intravascular catheter. The catheter can be adapted to incorporate an injection port and retractable needle for therapeutic delivery. The performance of the β-detection catheter was assessed in vitro with various β-emitting radionuclides and ex vivo in hearts of pigs following systemic injection of 18F-fluorodeoxyglucose (18F-FDG) at 1-week post myocardial infarction. Regional catheter-based endocardial measurements of 18F activity were compared to regional tissue activity from PET/CT images and gamma counting. The β-detection catheter demonstrated sensitive in vitro detection of β-radiation from 22Na (β+), 18F (β+), and 204Tl (β−), with minimal sensitivity to γ-radiation. For 18F, the catheter demonstrated a sensitivity of 4,067 counts/s/μCi in contact and a spatial resolution of 1.1 mm FWHM. Ex vivo measurements of endocardial 18F activity with the β-detection catheter in the chronic pig infarct model demonstrated good qualitative and quantitative correlation with regional tissue activity from PET/CT images and gamma counting. The prototype β-detection catheter demonstrates sensitive and selective detection of β− and β+ emissions over a wide range of energies and enables high-fidelity ex vivo characterization of endocardial activity from systemically delivered 18F-FDG.
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DOI：
10.1161/circinterventions.112.000422
发表时间：
2013-12
期刊：
Circulation. Cardiovascular interventions
影响因子：
--
作者：
Behfar A;Latere JP;Bartunek J;Homsy C;Daro D;Crespo-Diaz RJ;Stalboerger PG;Steenwinckel V;Seron A;Redfield MM;Terzic A
通讯作者：
Terzic A
DOI：
10.1016/0735-1097(93)90582-l
发表时间：
1993-11-15
影响因子：
24
作者：
GROPLER, RJ;GELTMAN, EM;SIEGEL, BA
通讯作者：
SIEGEL, BA
人类急性心肌梗塞后心脏α（V）β（3）整联蛋白表达。
DOI：
10.1136/heartjnl-2016-310115
发表时间：
2017-04
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Jenkins WS;Vesey AT;Stirrat C;Connell M;Lucatelli C;Neale A;Moles C;Vickers A;Fletcher A;Pawade T;Wilson I;Rudd JH;van Beek EJ;Mirsadraee S;Dweck MR;Newby DE
通讯作者：
Newby DE
影响因子：
24
作者：
Malliaras, Konstantinos;Makkar, Raj R.;Smith, Rachel R.;Cheng, Ke;Wu, Edwin;Bonow, Robert O.;Marban, Linda;Mendizabal, Adam;Cingolani, Eugenio;Johnston, Peter V.;Gerstenblith, Gary;Schuleri, Karl H.;Lardo, Albert C.;Marban, Eduardo
通讯作者：
Marban, Eduardo
DOI：
10.1161/atvbaha.112.300310
发表时间：
2012-11
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Chen W;Saxena A;Li N;Sun J;Gupta A;Lee DW;Tian Q;Dobaczewski M;Frangogiannis NG
通讯作者：
Frangogiannis NG