Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment
Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment
复制标题
磁性功能化碳纳米管作为癌症淋巴结转移治疗的药物载体
DOI：
10.1016/j.ejca.2011.03.018
复制
发表时间：
2011-08-01
影响因子：
8.4
通讯作者：
Fu, Deliang
中科院分区：
文献类型：
--
作者：
Yang, Feng;Jin, Chen;Fu, Deliang
使用碳基纳米材料作为载体用于将化疗药物递送至癌症的策略已经被很好地描述。在这里，提出了一种新的基于功能化碳纳米管（fCNTs）的磁性磁性纳米靶向药物递送系统，其目的是改善淋巴结受累的癌症的结果。比较了磁性多壁碳纳米管（mMWNTs）负载吉西他滨（GEM）与磁性活性炭颗粒（mACs）负载GEM的体内外潜在治疗效果。mMWNTs-GEM和mACs-GEM均具有与游离药物相似的体外抗肿瘤活性。皮下注射载GEM磁性纳米颗粒可成功消退和抑制磁场下的淋巴结转移，mMWNTs-GEM上级优于mACs-GEM，且高剂量组比低剂量组更有效。使用mMWNTs的化疗药物的超淋巴递送的成功应用突出了fCNT用于未来癌症转移治疗的临床潜力，具有高疗效和最小的副作用。(C)2011爱思唯尔有限公司版权所有。
Strategies using carbon-based nanomaterials as carriers for delivering chemotherapeutic drugs to cancers have been described well. Here a novel magnetic lymphatic-targeting drug-delivery system, based on functionalised carbon nanotubes (fCNTs), is presented with the aim of improving the outcome of cancer with lymph node involvement. The potential therapeutic effect of gemcitabine (GEM) loading magnetic multiwalled carbon nanotubes (mMWNTs) was compared with that of GEM loading magnetic-activated carbon particles (mACs) in vitro and in vivo. mMWNTs-GEM and mACs-GEM both had high anti-tumour activity in vitro similar to free drug. Subcutaneous administration of GEM loading magnetic nanoparticles resulted in successful regression and inhibition of lymph node metastasis under the magnetic field, with mMWNTs-GEM superior to mACs-GEM, and more effectively in the high-dose versus low-dose groups. The successful application of Ultra-lymphatic delivery of chemotherapeutics using mMWNTs highlights the clinical potential of fCNTs for future cancer metastasis treatment with high efficacy and minimum side-effects. (C) 2011 Elsevier Ltd. All rights reserved.