Preparation, structural characterisation and antibacterial properties of Ga-doped sol–gel phosphate-based glass
Preparation, structural characterisation and antibacterial properties of Ga-doped sol–gel phosphate-based glass
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DOI：
10.1007/s10853-008-3237-2
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发表时间：
2009-02
影响因子：
4.5
通讯作者：
D. Pickup;S. Valappil;R. Moss;H. Twyman;P. Guerry;Mark E. Smith;Michael T. Wilson;J. Knowles;R. J. Newport
中科院分区：
文献类型：
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作者：
D. Pickup;S. Valappil;R. Moss;H. Twyman;P. Guerry;Mark E. Smith;Michael T. Wilson;J. Knowles;R. J. Newport
研究了一种溶胶-凝胶法制备在抗菌器件中具有潜在应用前景的掺ga磷酸盐基玻璃。制备了组分为（CaO）0.30(Na2O)0.20−x(Ga2O3)x(P2O5)0.50的样品，其中x= 0和0.03，并比较了掺镓样品与不含镓样品的结构和性能。对31p MAS NMR数据的分析表明，在溶胶-凝胶反应中加入镓增加了磷酸盐网络的连通性，而牺牲了羟基。元素分析结果表明，无镓样品含有更多的氢，FTIR光谱显示样品中-OH基团的浓度更高，这一前提得到了支持。镓k边扩展x射线吸收精细结构和x射线吸收近边结构数据显示镓离子由6个氧原子配位。与x射线吸收数据一致，高能XRD结果也表明Ga3+离子相对于氧呈八面体配位。抗菌研究表明，与对照相比，含Ga3+离子的样品对金黄色葡萄球菌具有显著的活性。
A sol–gel preparation of Ga-doped phosphate-based glass with potential application in antimicrobial devices has been developed. Samples of composition (CaO)0.30(Na2O)0.20−x(Ga2O3)x(P2O5)0.50wherex= 0 and 0.03 were prepared, and the structure and properties of the gallium-doped sample compared with those of the sample containing no gallium. Analysis of the31P MAS NMR data demonstrated that addition of gallium to the sol–gel reaction increases the connectivity of the phosphate network at the expense of hydroxyl groups. This premise is supported by the results of the elemental analysis, which showed that the gallium-free sample contains significantly more hydrogen and by FTIR spectroscopy, which revealed a higher concentration of –OH groups in that sample. Ga K-edge extended X-ray absorption fine structure and X-ray absorption near-edge structure data revealed that the gallium ions are coordinated by six oxygen atoms. In agreement with the X-ray absorption data, the high-energy XRD results also suggest that the Ga3+ions are octahedrally coordinated with respect to oxygen. Antimicrobial studies demonstrated that the sample containing Ga3+ions had significant activity againstStaphylococcus aureuscompared to the control.