Impact of intracellular innate immune receptors on immunometabolism.
Impact of intracellular innate immune receptors on immunometabolism.
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DOI：
10.1038/s41423-021-00780-y
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发表时间：
2022-03
影响因子：
24.1
通讯作者：
Ting JP
中科院分区：
文献类型：
--
作者：
Chou WC;Rampanelli E;Li X;Ting JP
免疫代谢是免疫细胞激活时无氧糖酵解、氧化磷酸化和代谢物合成的代谢重编程，作为调节天然和获得性免疫细胞亚群的动态平衡、激活、增殖和分化的重要因素，在免疫中起着关键作用。上皮细胞和其他基质细胞对不同刺激信号的代谢变化在感染、炎症、癌症、自身免疫性疾病和代谢紊乱中也是至关重要的。PI3K-AKT-mTOR和LKB1-AMPK信号通路之间的串扰对于调节免疫和非免疫细胞代谢是至关重要的。免疫细胞与新陈代谢的双向相互作用是当前研究的热点。Toll样受体、细胞因子受体、T细胞和B细胞受体可激活多条下游代谢通路。然而，细胞内先天免疫感受器/受体如何与代谢途径相交还不太清楚。本文旨在探讨免疫代谢与几种细胞内天然免疫受体的功能之间的关系，如黑色素瘤2(AIM2)样受体缺失的核苷酸结合和富含亮氨酸重复序列的受体(NLR，或NOD样受体)，以及干扰素基因的环二核苷酸受体刺激物(STINR)。我们将重点介绍最近的进展，并描述这些细胞内天然免疫受体对多种代谢途径的影响。只要合适，本综述将提供病原性感染、自身免疫性疾病、癌症、代谢紊乱和/或炎症性肠道疾病的简短背景联系。
Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis, oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has gained importance as a regulator of the homeostasis, activation, proliferation, and differentiation of innate and adaptive immune cell subsets that function as key factors in immunity. Metabolic changes in epithelial and other stromal cells in response to different stimulatory signals are also crucial in infection, inflammation, cancer, autoimmune diseases, and metabolic disorders. The crosstalk between the PI3K–AKT–mTOR and LKB1–AMPK signaling pathways is critical for modulating both immune and nonimmune cell metabolism. The bidirectional interaction between immune cells and metabolism is a topic of intense study. Toll-like receptors (TLRs), cytokine receptors, and T and B cell receptors have been shown to activate multiple downstream metabolic pathways. However, how intracellular innate immune sensors/receptors intersect with metabolic pathways is less well understood. The goal of this review is to examine the link between immunometabolism and the functions of several intracellular innate immune sensors or receptors, such as nucleotide-binding and leucine-rich repeat-containing receptors (NLRs, or NOD-like receptors), absent in melanoma 2 (AIM2)-like receptors (ALRs), and the cyclic dinucleotide receptor stimulator of interferon genes (STING). We will focus on recent advances and describe the impact of these intracellular innate immune receptors on multiple metabolic pathways. Whenever appropriate, this review will provide a brief contextual connection to pathogenic infections, autoimmune diseases, cancers, metabolic disorders, and/or inflammatory bowel diseases.
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