Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium.
Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium.
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DOI：
10.1186/s13058-023-01673-w
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发表时间：
2023-06-20
期刊：
影响因子：
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中科院分区：
文献类型：
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Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes. An international pooled cohort of 8091 BRCA1/2 variant carriers was used for retrospective and prospective analyses separately for premenopausal and postmenopausal women. Cox regression was used to estimate breast cancer risk associations with height, BMI, and weight change. In the retrospective analysis, taller height was associated with risk of premenopausal breast cancer for BRCA2 variant carriers (HR 1.20 per 10 cm increase, 95% CI 1.04–1.38). Higher young-adult BMI was associated with lower premenopausal breast cancer risk for both BRCA1 (HR 0.75 per 5 kg/m2, 95% CI 0.66–0.84) and BRCA2 (HR 0.76, 95% CI 0.65–0.89) variant carriers in the retrospective analysis, with consistent, though not statistically significant, findings from the prospective analysis. In the prospective analysis, higher BMI and adult weight gain were associated with higher postmenopausal breast cancer risk for BRCA1 carriers (HR 1.20 per 5 kg/m2, 95% CI 1.02–1.42; and HR 1.10 per 5 kg weight gain, 95% CI 1.01–1.19, respectively). Anthropometric measures are associated with breast cancer risk for BRCA1 and BRCA2 variant carriers, with relative risk estimates that are generally consistent with those for women from the general population. The online version contains supplementary material available at 10.1186/s13058-023-01673-w.
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DOI：
10.1093/annonc/mdu042
发表时间：
2014-10
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Chan DSM;Vieira AR;Aune D;Bandera EV;Greenwood DC;McTiernan A;Navarro Rosenblatt D;Thune I;Vieira R;Norat T
通讯作者：
Norat T
影响因子：
51.1
作者：
Green, Jane;Cairns, Benjamin J.;Casabonne, Delphine;Wright, F. Lucy;Reeves, Gillian;Beral, Valerie
通讯作者：
Beral, Valerie
BRCA1和BRCA2突变载体中乳腺癌和卵巢癌的病理学：BRCA1/2修饰符研究者联盟的结果（CIMBA）。
DOI：
10.1158/1055-9965.epi-11-0775
发表时间：
2012-01
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Mavaddat N;Barrowdale D;Andrulis IL;Domchek SM;Eccles D;Nevanlinna H;Ramus SJ;Spurdle A;Robson M;Sherman M;Mulligan AM;Couch FJ;Engel C;McGuffog L;Healey S;Sinilnikova OM;Southey MC;Terry MB;Goldgar D;O'Malley F;John EM;Janavicius R;Tihomirova L;Hansen TV;Nielsen FC;Osorio A;Stavropoulou A;Benítez J;Manoukian S;Peissel B;Barile M;Volorio S;Pasini B;Dolcetti R;Putignano AL;Ottini L;Radice P;Hamann U;Rashid MU;Hogervorst FB;Kriege M;van der Luijt RB;HEBON;Peock S;Frost D;Evans DG;Brewer C;Walker L;Rogers MT;Side LE;Houghton C;EMBRACE;Weaver J;Godwin AK;Schmutzler RK;Wappenschmidt B;Meindl A;Kast K;Arnold N;Niederacher D;Sutter C;Deissler H;Gadzicki D;Preisler-Adams S;Varon-Mateeva R;Schönbuchner I;Gevensleben H;Stoppa-Lyonnet D;Belotti M;Barjhoux L;GEMO Study Collaborators;Isaacs C;Peshkin BN;Caldes T;de la Hoya M;Cañadas C;Heikkinen T;Heikkilä P;Aittomäki K;Blanco I;Lazaro C;Brunet J;Agnarsson BA;Arason A;Barkardottir RB;Dumont M;Simard J;Montagna M;Agata S;D'Andrea E;Yan M;Fox S;kConFab Investigators;Rebbeck TR;Rubinstein W;Tung N;Garber JE;Wang X;Fredericksen Z;Pankratz VS;Lindor NM;Szabo C;Offit K;Sakr R;Gaudet MM;Singer CF;Tea MK;Rappaport C;Mai PL;Greene MH;Sokolenko A;Imyanitov E;Toland AE;Senter L;Sweet K;Thomassen M;Gerdes AM;Kruse T;Caligo M;Aretini P;Rantala J;von Wachenfeld A;Henriksson K;SWE-BRCA Collaborators;Steele L;Neuhausen SL;Nussbaum R;Beattie M;Odunsi K;Sucheston L;Gayther SA;Nathanson K;Gross J;Walsh C;Karlan B;Chenevix-Trench G;Easton DF;Antoniou AC;Consortium of Investigators of Modifiers of BRCA1/2
通讯作者：
Consortium of Investigators of Modifiers of BRCA1/2
影响因子：
3.8
作者：
Loi, S;Milne, RL;Phillips, KA
通讯作者：
Phillips, KA
影响因子：
120.7
作者：
Kuchenbaecker, Karoline B.;Hopper, John L.;Antoniou, Antonis C.
通讯作者：
Antoniou, Antonis C.