Dynamic mapping of human cortical development during childhood through early adulthood
Dynamic mapping of human cortical development during childhood through early adulthood
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DOI：
10.1073/pnas.0402680101
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发表时间：
2004-05-25
影响因子：
11.1
通讯作者：
Thompson, PM
中科院分区：
文献类型：
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作者：
Gogtay, N;Giedd, JN;Thompson, PM
我们使用定量四维图和延时序列报道了4-21岁人类皮层灰质发育的动态解剖序列。对13名健康儿童进行了研究，每2年对他们进行解剖性脑MRI扫描，持续8-10年。通过使用皮层表面和脑沟地标模型以及灰质密度统计模型，可以在时空上详细地观察人类皮层在不同年龄范围内的发育情况。由此产生的延时“电影”揭示了(i)高阶联想皮层只有在低阶体感和视觉皮层（它们整合的功能）发育成熟后才成熟，（ii）从系统发育上讲，较老的大脑区域比较新的大脑区域成熟得早。与正常皮质发育的直接比较可能有助于理解一些神经发育障碍，如儿童精神分裂症或自闭症。
We report the dynamic anatomical sequence of human cortical gray matter development between the age of 4-21 years using quantitative four-dimensional maps and time-lapse sequences. Thirteen healthy children for whom anatomic brain MRI scans were obtained every 2 years, for 8-10 years, were studied. By using models of the cortical surface and sulcal landmarks and a statistical model for gray matter density, human cortical development could be visualized across the age range in a spatiotemporally detailed time-lapse sequence. The resulting time-lapse "movies" reveal that (i) higher-order association cortices mature only after lower-order somatosensory and visual cortices, the functions of which they integrate, are developed, and (ii) phylogenetically older brain areas mature earlier than newer ones. Direct comparison with normal cortical development may help understanding of some neurodevelopmental disorders such as childhood-onset schizophrenia or autism.