An antigen valence theory to explain the evolution and organization of the humoral immune response
An antigen valence theory to explain the evolution and organization of the humoral immune response
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DOI：
10.1038/icb.1997.95
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发表时间：
1997-12-01
影响因子：
4
通讯作者：
Hodgkin, PD
中科院分区：
文献类型：
--
作者：
Hodgkin, PD
抗体产生的三种模式——天然的、T非依赖性（TI）和T依赖性（TD）在脊椎动物物种中是保守的，这表明它们在抵御病原体方面各自都起着重要作用。在此，我利用一个人工“体系”来论证，抗体产生的这三种模式代表了为了最佳地应对不同价态的抗原而进化出的层次。因此，看似更复杂的TD反应并没有取代体液免疫反应中的天然成分和TI成分。此外，每个抗体层次所表现出的同种型、体细胞突变和免疫记忆方面的特征差异适合它们所针对的表面结构范围。还提出TD和TI激活途径处于一个连续体的两端，抗原和T细胞衍生信号的整合有助于B细胞做出关于同种型选择、增殖和分泌的决策，从而将获得保护的时间缩至最短。
The three modes of antibody production, natural, T independent (TI) and T dependent (TD) are conserved among vertebrate species suggesting an important role for each in protection against pathogens. Here, I use an artificial 'universe' to argue that the three modes of antibody production represent layers that evolved to deal optimally with antigens of different valence. Thus, the apparently more sophisticated TD response has not superseded the natural and TI components of the humoral immune response. Furthermore, the characteristic differences in isotype, somatic mutation and memory displayed by each antibody layer are appropriate for their targeted range of surface structures. It is also suggested that the TD and TI activation arms are at the extremes of a continuum, with signal integration of antigen and T cell-derived signals contributing to B cell decisions about isotype selection, proliferation and secretion that minimize the time to protection.