THE EFFECT OF ACUTE LITHIUM ADMINISTRATION ON BRAIN MONOAMINE SYNTHESIS AND THE PRECURSOR AMINO-ACIDS TYROSINE AND TRYPTOPHAN IN BRAIN AND PLASMA IN RATS
THE EFFECT OF ACUTE LITHIUM ADMINISTRATION ON BRAIN MONOAMINE SYNTHESIS AND THE PRECURSOR AMINO-ACIDS TYROSINE AND TRYPTOPHAN IN BRAIN AND PLASMA IN RATS
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DOI：
10.1007/bf01251911
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
BERGGREN, U
中科院分区：
文献类型：
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作者：
BERGGREN, U
研究了氯化锂单次静脉注射对大鼠脑内单胺合成、脑内及血浆中酪氨酸和色氨酸水平的影响。急性Li给药降低了脑酪氨酸水平，这很可能是由于血浆酪氨酸水平降低。脑色氨酸水平基本未受影响，而血浆色氨酸水平在Li给药后8 h略有下降。脑儿茶酚胺合成在注射Li后4 h降低，48 h升高。脑内5-羟色胺（5-HT）合成在注射Li后各时间间隔均明显降低。急性Li给药对大鼠脑单胺合成的影响并不主要是由于其对大鼠脑酪氨酸和色氨酸水平的影响。急性Li给药似乎对5-羟色胺合成的影响大于对儿茶酚胺合成的影响。
The effect of a single i.p. injection of lithium chloride on brain monoamine synthesis, tyrosine and tryptophan levels in brain and plasma in rats was studied. Acute Li administration decreased brain tyrosine levels, which most likely was due to decreased plasma tyrosine levels. Brain tryptophan levels were mainly unaffected whereas plasma tryptophan levels were slightly decreased at 8 h after Li administration. Brain catecholamine synthesis was decreased at 4 h and increased at 48 h after the injection of Li. Brain 5-hydroxytryptamine (5-HT) synthesis was decreased at all time intervals after the injection of Li. The effects of acute Li administration on brain monoamine synthesis are not mainly due to its effect on brain tyrosine and tryptophan levels in rats. Acute Li administration appears to affect 5-HT synthesis to a greater extent than it affects catecholamine synthesis.