Genetic susceptibility to Leishmania: IL-12 responsiveness in T(H)1 cell development
Genetic susceptibility to Leishmania: IL-12 responsiveness in T(H)1 cell development
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DOI：
10.1126/science.271.5251.984
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发表时间：
1996-02-16
期刊：
影响因子：
56.9
通讯作者：
Murphy, KM
中科院分区：
文献类型：
--
作者：
Guler, ML;Gorham, JD;Murphy, KM
T淋巴细胞的遗传背景影响T辅助细胞（T-H）表型的发育，导致某些小鼠品系对病原体（如硕大利什曼原虫）的抗性或易感性。通过体外模型系统，检测到BALB/c和B10.D2小鼠之间T细胞对白细胞介素-12（IL-12）的应答性维持的差异。尽管来自两个品系的初始T细胞最初对IL-12应答，但BALB/c T细胞在体外用抗原刺激后丧失IL-12应答性，即使当与B10.D2 T细胞共培养时也是如此。BALB/c小鼠对L.主要的原因可能是产生IL-12诱导的T（H）1应答的能力丧失，而不是IL-4诱导的T（H）2应答。
The genetic background of T lymphocytes influences development of the T helper (T-H) phenotype, resulting in either resistance or susceptibility of certain mouse strains to pathogens such as Leishmania major. With an in vitro model system, a difference in maintenance of responsiveness of T cells to interleukin-12 (IL-12) was detected between BALB/c and B10.D2 mice, Although naive T cells from both strains initially responded to IL-12, BALB/c T cells lost IL-12 responsiveness after stimulation with antigen in vitro, even when cocultured with B10.D2 T cells, Thus, susceptibility of BALB/c mice to infection with L. major may derive from the loss of the ability to generate IL-12-induced T(H)1 responses rather than from an IL-4-induced T(H)2 response.