Two new sesquiterpenes from Alisma orientalis.
Two new sesquiterpenes from Alisma orientalis.
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DOI：
10.1248/cpb.55.905
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发表时间：
2007-06
影响因子：
1.7
通讯作者：
Zhi-Yong Jiang;Xue-mei Zhang;Jun Zhou;Feng-xue Zhang;Ji-Jun Chen;Yang Lü;Li Wu;Q. Zheng
中科院分区：
文献类型：
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作者：
Zhi-Yong Jiang;Xue-mei Zhang;Jun Zhou;Feng-xue Zhang;Ji-Jun Chen;Yang Lü;Li Wu;Q. Zheng
从中华人民共和国四川省采集的泽泻根茎中分离出两种新的倍半萜类化合物，命名为泽泻 A (1) 和 B (2)。基于光谱分析（1D 和 2D NMR 数据，包括 HSQC、HMBC、COSY 和 ROESY）和 X 射线晶体学分析，阐明了它们的结构。抗乙型肝炎病毒（HBV）生物测定显示，化合物1在体外表现出中等抗HBV活性，对于HBsAg的IC50为：1.1 microM，对于HBeAg：14.7 microM。
Two new sesquiterpenoids named alismorientols A (1) and B (2) were isolated from the rhizomes of Alisma orientalis collected in Sichuan province, People's Republic of China. Their structures were elucidated based on spectroscopic analyses (1D and 2D NMR data including HSQC, HMBC, COSY, and ROESY) and X-ray crystallographic analysis. Anti-hepatitis B virus (HBV) bioassay revealed that compound 1 showed moderate anti-HBV activity in vitro with IC50 for HBsAg: 1.1 microM, for HBeAg: 14.7 microM.