Enhanced neoplastic transformation due to protracted exposures of fission-spectrum neutrons: biophysical model.
Enhanced neoplastic transformation due to protracted exposures of fission-spectrum neutrons: biophysical model.
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由于裂变谱中子的长期暴露而增强肿瘤转化：生物物理模型。
DOI：
10.1080/09553009114551311
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发表时间：
1991
影响因子：
2.6
通讯作者：
Elkind,MM
中科院分区：
文献类型：
--
作者：
Elkind,MM
1. 1982年，Hill等报道了美国阿贡国家实验室JANUS反应堆产生的裂变谱中子的延长照射，比短时间照射同等剂量更有效地转化C3 H 10 TI/2细胞。对于所用的剂量范围和剂量率，还报告了1 OT 1/2细胞的存活率没有变化。1984年，Hill等人在其原始报告的基础上，更详细地描述了在高剂量率和低剂量率下给予低剂量后的转化诱导曲线形状。这第二份报告引起了许多研究人员的注意，并产生了一系列给编辑的信（Barendsen 1985，Rossi和Kellerer 1986，Burch和Chesters 1986）。在适当的时候，对这些信件的回复都被发表了（Elkind and Hill，1985，1986 a，B）。根据Hill et al. (1982，1984 a），一些对培养细胞的进一步研究证实了由于延长暴露于裂变谱中子而导致的转化频率增强，而其他研究则没有。Hill等人（1985年）发现，在4天时间内输送5个相等分数的高剂量率裂变谱中子，导致10 TI/2细胞的转化频率与先前报告的低剂量率结果一致; Jones等人（1989）用叙利亚仓鼠胚胎细胞获得了类似的结果;和Redpath et al. (1990 a，B）也观察到用人细胞杂合体的增强的转化。在后三项研究中，都使用了JANUS裂变谱中子，但在每种情况下使用了不同的终点。Hill等人使用生长停滞细胞片中的病灶形成，Jones等人采用了转化的菌落形态学，Redpath等人使用肿瘤相关细胞表面抗原的诱导作为表型变化的指标。因此，使用相同的中子源，三个不同的终点产生了定性相似的结果。两项研究显然没有显示转化频率的增加。这些是Hieber et al.（1987）和Balcer-Kubiczek et al.（1988年）。在这两种情况下，都使用了10 T1/2细胞;然而，Hieber等人用来自”Am”的α粒子进行辐照，Balcer-Kubiczek等人使用了美国马里兰州贝塞斯达武装部队放射生物学研究所的TRIGA反应堆产生的裂变谱中子。使用不同来源的“高LET”粒子提出了一种可能性，即这两项研究的非确认性结果可能主要是由于辐射质量的差异，尽管如下文所述，其他技术考虑也可能发挥了作用。
1. Background In 1982 Hill et al. reported that extended exposures of fission-spectrum neutrons, produced by the JANUS reactor at the Argonne National Laboratory USA, neoplastically transformed C3H 10TI/2 cells more efficiently than equivalent doses delivered in a brief exposure. For the dose range and dose rates that were used it was also reported that the survival of 1OT1/2 cells did not change. In 1984 Hill et al. added to their original report by describing in greater detail the shapes of the transformation induction curves following low doses delivered at high and low dose-rates. This second report attracted the attention of a number of researchers and gave rise to a series of Letters to the Editor (Barendsen 1985, Rossi and Kellerer 1986, Burch and Chesters 1986). In due course replies to each of these Letters were published (Elkind and Hill 1985, 1986a, b). Since the reports of Hill et al.(1982, 1984 a), some of the further studies with cells in culture confirmed an enhanced transformtion frequency due to protracted exposures to fission-spectrum neutrons and others did not. Hill et al.(1985) found that five equal fractions of high-dose-rate fission-spectrum neutrons, delivered over a 4-day period, resulted in transformation frequencies of 10TI/2 cells consistent with the results with low dose-rates that had been reported earlier; Jones et al.(1989) obtained similar results with Syrian hamster embryo cells; and Redpath et al.(1990 a, b) also observed enhanced transformation with a human-cell hybrid. In all of the latter three studies JANUS fission-spectrum neutrons were used, but in each case different endpoints were employed. Focus formation in a sheet of growth-arrested cells was used by Hill et al., transformed colonial morphology was employed by Jones et al., and the induction of a tumour-associated cell-surface antigen was the indicator of phenotypic change used by Redpath et al. Thus, with the same source of neutrons, three different endpoints yielded qualitatively similar results.Two studies clearly did not reveal an enhanced frequency of transformation. These were those of Hieber et al.(1987), and Balcer-Kubiczek et al.(1988). In both instances 10T1/2 cells were used; however, Hieber et al. irradiated with a-particles from"" Am, and Balcer-Kubiczek et al. employed the fission-spectrum neutrons produced by the TRIGA reactor at the Armed Forces Radiobiological Research Institute, Bethesda, Maryland, USA. The use of different sources of'high-LET'particles raised the possibility that the non-confirmatory results of these two studies could be due primarily to differences in the qualities of the radiations although, as noted below, other technical considerations may also have played a role.
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培养的哺乳动物细胞的放射生物学
DOI：
--
发表时间：
1967
期刊：
影响因子：
--
作者：
M. Elkind;G. Whitmore
通讯作者：
G. Whitmore
多次低剂量裂变谱中子可增强肿瘤转化。
影响因子：
3.4
作者：
Hill,CK;Carnes,BA;Han,A;Elkind,MM
通讯作者：
Elkind,MM
降低 60Co γ 射线剂量率修复细胞杀伤和肿瘤转化
影响因子：
11.2
作者：
A. Han;C. Hill;M. M. Elkind
通讯作者：
M. M. Elkind
60Co 伽马射线的多重分割可减少体外肿瘤转化。
影响因子：
4.7
作者：
Colin K. Hill;A. Han;A. Han;Franco M. Buonaguro;M. M. Elkind;M. M. Elkind
通讯作者：
M. M. Elkind
低剂量率的裂变谱中子增强线性低剂量区域（0-10 cGy）的肿瘤转化。
DOI：
10.1080/09553008414551011
发表时间：
1984
期刊：
International journal of radiation biology and related studies in physics, chemistry, and medicine
影响因子：
--
作者：
Hill,CK;Han,A;Elkind,MM
通讯作者：
Elkind,MM