Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid.
Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid.
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全氟辛酸和全氟辛烷磺酸的致癌性。
DOI：
10.1016/s1470-2045(23)00622-8
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Machala,Mi
中科院分区：
文献类型：
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作者：
Zahm,Shelia;Bonde,JensPeter;Chiu,WeihsuehA;Hoppin,Jane;Kanno,Jun;Abdallah,Mohamed;Blystone,ChadR;Calkins,MiriamM;Dong,Guang-Hui;Dorman,DavidC;Fry,Rebecca;Guo,Huan;Haug,LineS;Hofmann,JonathanN;Iwasaki,Motoki;Machala,Mi
2023年11月，来自11个国家的30名科学家组成的工作组在法国里昂的国际癌症研究机构（IARC）举行会议，最终确定他们对两种物质致癌性的评估：全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS），包括其相应的异构体和盐类。全氟辛酸被归类为“对人类致癌”（第1组），这是基于“充分”的实验动物致癌证据和“强烈”的暴露人体的机械证据。实验动物中癌症的证据是“充分的”，因为在药物非临床研究质量管理规范（GLP）研究中，在单一种属的两种性别中观察到良性和恶性肿瘤适当组合的发生率增加。在暴露于PFOA的人类中，机械证据是“强有力的”，因为发现PFOA会诱导表观遗传改变并具有免疫抑制作用。此外，肾细胞癌和睾丸癌在人类中的癌症证据“有限”。根据“强有力的”机械证据，全氟辛烷磺酸被归类为“可能对人类致癌”（2B类）。全氟辛烷磺酸在实验动物中致癌的证据“有限”，而在人类中致癌的证据“不足”。这些评估将在《2000年世界卫生组织
In November, 2023, a Working Group of 30 scientists from 11 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of two agents: perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), including their corresponding isomers and salts.PFOA was classified as “carcinogenic to humans”(Group 1) based on “sufficient” evidence for cancer in experimental animals and “strong” mechanistic evidence in exposed humans. The evidence for cancer in experimental animals was “sufficient” because an increased incidence of an appropriate combination of benign and malignant neoplasms was observed in both sexes of a single species in a Good Laboratory Practice (GLP) study. The mechanistic evidence was “strong” in exposed humans because PFOA was found to induce epigenetic alterations and to be immunosuppressive. Additionally, there was “limited” evidence for cancer in humans for renal cell carcinoma and testicular cancer. PFOS was classified as “possibly carcinogenic to humans”(Group 2B) based on “strong” mechanistic evidence. The evidence for cancer in experimental animals was “limited” for PFOS, and the evidence regarding cancer in humans was “inadequate”. These assessments will be published in Volume 135 of the