A new direction for kinesin
A new direction for kinesin
复制标题
驱动蛋白的新方向
作者：
F. Malik;R. Vale
即使在Ned，Walker等人只检测到负端定向的运动。提到内德可以产生正向移动，也许是在适当的监管下。如果不是Schliwa和他的同事们对来自淡水阿米巴网状阿米巴的动力蛋白(M，400-500K亚基)细胞器运输马达的研究，这一想法似乎是异端的。这种马达诱导珠子沿着微管双向移动。但很难排除类似激动素的污染物对脉冲端定向运动负责的可能性。然而，他们最近的研究得出结论，网状粘动力蛋白是一种更坚实的地面上的双向马达。
Even though only minus-end-directed motility was detected with ned, Walker et al. mention that ned could produce plusend-directed movement, perhaps under appropriate regulation. This idea would seem heretical were it not for the work of Schliwa and colleagues"'on a dynein-like (M, 400-500K subunit) organelle transport motor from the freshwater amoeba, Reticulomyxa. This motor induces bidirectional movement of beads along microtubules"; but it was difficult to rule out the possibility that a kinesin-like contaminant is responsible for the plusend-directed motility. Their recent study, however, puts the conclusion that the Reticulomyxa dynein is a bidirectional motor on firmer ground.
有证据表明驱动蛋白的头部足以在体外产生力和运动。
DOI：
10.1126/science.2142332
发表时间：
1990
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Yang,JT;Saxton,WM;Stewart,RJ;Raff,EC;Goldstein,LS
通讯作者：
Goldstein,LS