Mangelonoids A and B, Two Pairs of Macrocyclic Diterpenoid Enantiomers from Croton mangelong.
Mangelonoids A and B, Two Pairs of Macrocyclic Diterpenoid Enantiomers from Croton mangelong.
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DOI：
10.1021/acs.orglett.8b01608
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发表时间：
2018-06
期刊：
影响因子：
5.2
通讯作者：
Wei-yi Zhang;Jin-Xin Zhao;Li Sheng;Yao-Yue Fan;Jing-Ya Li;K. Gao;J. Yue
中科院分区：
文献类型：
--
作者：
Wei-yi Zhang;Jin-Xin Zhao;Li Sheng;Yao-Yue Fan;Jing-Ya Li;K. Gao;J. Yue
（+）-和（-）-MangeltenA和B是两对新的大环二萜对映体，具有前所未有的双环[9.3.1]十五烷核和罕见的桥头双键。它们的结构明确地建立了光谱数据，X射线晶体学，和电子圆二色性分析。提出了这些化合物的合理生物合成途径。（-）-芒果苷A对NF-κB具有抑制作用，IC 50值为7.27 ± 1.30 μM。
(+)- and (-)-Mangelonoids A and B, two pairs of novel macrocyclic diterpenoid enantiomers featuring an unprecedented bicyclo[9.3.1]pentadecane core and a rare bridgehead double bond, were isolated from Croton mangelong. Their structures were unambiguously established using spectroscopic data, X-ray crystallography, and electronic circular dichroism analysis. A plausible biosynthesis pathway for these compounds was proposed. (-)-Mangelonoid A exhibited NF-κB inhibition with an IC50 value of 7.27 ± 1.30 μM.