Working together to shape the endometrial cancer research agenda: The top ten unanswered research questions
Working together to shape the endometrial cancer research agenda: The top ten unanswered research questions
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DOI：
10.1016/j.ygyno.2016.08.333
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发表时间：
2016-11-01
影响因子：
4.7
通讯作者：
Crosbie, Emma J.
中科院分区：
文献类型：
--
作者：
Wan, Y. Louise;Beverley-Stevenson, Rachel;Crosbie, Emma J.
背景子宫内膜癌是发达国家最常见的妇科恶性肿瘤，其发病率呈上升趋势。作为一个直接的后果，更多的妇女死于EC，尽管在护理和提高生存率的进步。缺乏研究活动和资金，也缺乏公众对电子商务的认识。我们试图让患者、护理人员和医疗保健专业人员参与进来，以确定EC方法学中最重要的未回答的研究问题。优先级设置方法是由詹姆斯·林德联盟开发的，包括四个关键阶段：收集研究问题;根据现有证据检查这些问题;临时优先级;和最终的共识会议，在此期间，前十个未回答的研究问题是使用修改后的名义组方法达成一致。我们的第一次在线调查产生了786个人提交的413名受访者，其中211人是EC幸存者或照顾者，并从其中产生了202个独特的未回答的研究问题。253人，包括108 EC幸存者和照顾者，完成了在线临时优先级调查。最后的30个问题在最终的共识会议上排名。我们的前十名涵盖了这种疾病的患者经验的广度，包括制定个性化的风险评分，完善专家转诊标准，了解不同类型EC的潜在生物学，开发新的个性化治疗和预防策略，预后和预测生物标志物，提高公众意识和心理问题的干预措施。在确定了EC中十大未回答的研究问题后，我们希望这能激励研究人员，医疗保健专业人员和公众合作，协调和投资研究，以改善受EC影响的女性的生活。(C)2016年6月，作者。爱思唯尔公司出版
Background. Endometrial cancer (EC) is the most common gynaecological cancer in developed nations and its incidence is rising. As a direct consequence, more women are dying from EC despite advances in care and improved survivorship. There is a lack of research activity and funding, as well as public awareness about EC. We sought to engage patients, carers and healthcare professionals to identify the most important unanswered research questions in EC.Methodology. The priority setting methodology was developed by the James Lind Alliance and involved four key stages: gathering research questions; checking these against existing evidence; interim prioritisation; and a final consensus meeting during which the top ten unanswered research questions were agreed using modified nominal group methodology.Results. Our first online survey yielded 786 individual submissions from 413 respondents, of whom 211 were EC survivors or carers, and from which 202 unique unanswered research questions were generated. 253 individuals, including 108 EC survivors and carers, completed an online interim prioritisation survey. The resulting top 30 questions were ranked in a final consensus meeting. Our top ten spanned the breadth of patient experience of this disease and included developing personalised risk scoring, refining criteria for specialist referral, understanding the underlying biology of different types of EC, developing novel personalised treatment and prevention strategies, prognostic and predictive biomarkers, increasing public awareness and interventions for psychological issues.Conclusion. Having established the top ten unanswered research questions in EC, we hope this galvanises researchers, healthcare professionals and the public to collaborate, coordinate and invest in research to improve the lives of women affected by EC. (C) 2016 The Authors. Published by Elsevier Inc.