Transepithelial sodium absorption is increased in people of African origin
Transepithelial sodium absorption is increased in people of African origin
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DOI：
10.1161/01.hyp.38.1.76
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发表时间：
2001-07-01
期刊：
影响因子：
8.3
通讯作者：
MacGregor, GA
中科院分区：
文献类型：
--
作者：
Baker, EH;Ireson, NJ;MacGregor, GA
盐敏感性高血压在城市黑人人群中比在白人人群中更常见，后果也更严重。通过上皮钠通道增加的肾脏钠重吸收可能是黑人高血压发展的基础。通过鼻电位差测量，在利德尔综合征患者中检测到钠通道活性增加。对39名黑人正常血压者、106名黑人高血压者、51名白人正常血压者和61名白人高血压者进行了鼻电位差测量。同时测量血压、体重指数和24小时尿钠排泄量。黑人受试者的最大电位差显著高于白人受试者（P=0.009），但在调整年龄、性别、吸烟状况、体重指数和24小时尿钠排泄量后，正常血压组和高血压组之间的最大电位差无显著差异（黑人正常血压组为-21.6 +/- 1.0 mV，黑人高血压组为-21.5 +/- 0.7 mV，白人正常血压组为- 18.5 +/- 1.0 mV，白人高血压组为- 18.9 +/- 0.9 mV）。在种族和血压组中，鼻电位差异与血压或生化变量无关。鼻电位差（鼻钠通道活动的一项指标）在黑人中大于白人，但在正常血压组和高血压组之间没有差异。鼻电位差测量值的增加可能反映了黑人与白人相比钠转运的普遍上调，这可能有助于解释黑人高血压的高患病率，但不能解释不同种族群体之间的血压差异。
Salt-sensitive hypertension is more common and has more severe consequences in urban black populations than in white populations. Increased renal sodium reabsorption through epithelial sodium channels may underlie the development of high blood pressure in black people. Increased sodium channel activity has been detected in subjects with Liddle's syndrome by nasal potential difference measurements. Nasal potential difference measurements were made in 39 black normotensive, 106 black hypertensive, 51 white normotensive, and 61 white hypertensive subjects. Blood pressure, body mass index, and 24-hour urinary sodium excretion were also measured. Maximum potential difference was significantly higher in black subjects than in white subjects (P=0.009) but was not significantly different between normotensive and hypertensive subjects after adjustment for age, gender, current smoking status, body mass index, and 24-hour urinary sodium excretion (black normotensive, -21.6 +/- 1.0 mV; black hypertensive, -21.5 +/- 0.7 mv; white normotensive, - 18.5 +/- 1.0 mV; and white hypertensive subjects, - 18.9 +/- 0.9 mV). Nasal potential difference did not correlate with blood pressure or biochemical variables within ethnic and blood pressure groups. Nasal potential difference, an index of nasal sodium channel activity, is greater in black than in white people but does not differ between normotensive and hypertensive groups. Increased nasal potential difference measurements may reflect generalized upregulation of sodium transport in black people compared with white people, which may help to explain the high prevalence of hypertension in black people but would not explain differences in blood pressure within separate ethnic groups.