Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies.
Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies.
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DOI：
10.1586/14737175.2014.955854
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发表时间：
2014-10
影响因子：
4.3
通讯作者：
Lane TE
中科院分区：
文献类型：
--
作者：
Marro BS;Blanc CA;Loring JF;Cahalan MD;Lane TE
多发性硬化症(MS)是一种慢性中枢神经系统炎症性疾病。虽然广泛的治疗方法有效地减少了复发缓解型多发性硬化症患者的局灶性白质炎症和斑块形成的发生率，但该领域内的一个挑战是开发允许轴突保护和重新髓鞘形成的治疗方法。在过去的十年中，人们对利用神经前体细胞促进髓鞘再生的兴趣与日俱增。为了了解神经干细胞在慢性脱髓鞘环境中的功能，已经开发了几个优秀的临床前小鼠模型。一种被广泛接受的模型是感染易感小鼠，感染小鼠肝炎病毒(MHV)的嗜神经变种，这些小鼠经历了慢性脱髓鞘，表现出与MS患者相似的临床和组织病理学特征。结合病毒等环境因素可能引发多发性硬化症的可能性，MHV脱髓鞘模型提供了一个相关的小鼠模型，以评估移植到炎症介导的脱髓鞘环境中的神经干细胞的治疗潜力。
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS. While a broad range of therapeutics effectively reduce the incidence of focal white matter inflammation and plaque formation for patients with relapse-remitting forms of MS, a challenge within the field is to develop therapies that allow for axonal protection and remyelination. In the last decade, growing interest has focused on utilizing neural precursor cells (NPCs) to promote remyelination. To understand how NPCs function in chronic demyelinating environments, several excellent pre-clinical mouse models have been developed. One well accepted model is infection of susceptible mice with neurotropic variants of mouse hepatitis virus (MHV) that undergo chronic demyelination exhibiting clinical and histopathologic similarities to MS patients. Combined with the possibility that an environmental agent such as a virus could trigger MS, the MHV model of demyelination presents a relevant mouse model to assess the therapeutic potential of NPCs transplanted into an environment in which inflammatory-mediated demyelination is established.
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影响因子：
158.5
作者：
Chang, A;Tourtellotte, WW;Trapp, BD
通讯作者：
Trapp, BD
影响因子：
5.3
作者：
Balabanov, Roumen;Strand, Krystal;Popko, Brian
通讯作者：
Popko, Brian
影响因子：
3.3
作者：
Cristofanilli, M.;Cymring, B.;Sadiq, S. A.
通讯作者：
Sadiq, S. A.
影响因子：
5.9
作者：
Chen, Lu;Coleman, Ronald;Leang, Ronika;Ha Tran;Kopf, Alexandra;Walsh, Craig M.;Sears-Kraxberger, Ilse;Steward, Oswald;Macklin, Wendy B.;Loring, Jeanne F.;Lane, Thomas E.
通讯作者：
Lane, Thomas E.
影响因子：
3.7
作者：
Aharonowiz M;Einstein O;Fainstein N;Lassmann H;Reubinoff B;Ben-Hur T
通讯作者：
Ben-Hur T