BIT-MAPPED SOMATOSENSORY-EVOKED POTENTIALS IN THE FRAGILE-X SYNDROME
BIT-MAPPED SOMATOSENSORY-EVOKED POTENTIALS IN THE FRAGILE-X SYNDROME
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DOI：
10.1016/s0987-7053(05)80074-7
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发表时间：
1994-12-01
影响因子：
3
通讯作者：
BERGONZI, P
中科院分区：
文献类型：
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作者：
FERRI, R;MUSUMECI, SA;BERGONZI, P
对10例男性脆性X综合征（fraX）患者和9例正常人的19个头皮电极记录了中潜伏期体感诱发电位（MLSEP）。发现一名fraX患者在刺激右正中神经和左正中神经后分别呈现出所谓的“巨大"MLSEP，其N60的幅度约为60 μ V和40 μ V。在同一个病人中，右手轻敲诱发了左顶叶诱发的EEG尖峰。这些研究结果进一步支持了已经提出的几个fraX患者的癫痫图片与良性儿童癫痫与centrotemporal棘波之间的相似性。与对照组相比，其余9例患者记录的MLSEP的颜色映射显示，额叶区域的N30异常大，P27的振幅增加，顶叶区域，N60和P100也呈现异常的场分布，优先代表额叶区域。这些数据可能表明，在fraX综合征中存在主要涉及额叶（特别是辅助运动区）的皮质功能障碍，这可能支持这些患者中通常观察到的许多行为变化。
Middle-latency somatosensory evoked potentials (MLSEPs) were recorded from 19 scalp electrodes in ten male patients with the fragile X (fraX) syndrome and nine normal controls. One fraX patient was found presenting the so-called ''giant'' MLSEPs with an amplitude of N60 of about 60 mu V and of 40 mu V after stimulation of the right and left median nerves, respectively. Tapping of the right hand, in the same patient, induced the appearance of left parietal evoked EEG spikes. These findings further support the already suggested similarity between the epileptic picture of several fraX patients with that of the benign childhood epilepsy with centrotemporal spikes. Color mapping of the MLSEPs recorded in the remaining nine patients, when compared with the control group, showed an abnormally large N30 over the frontal regions, together with an increase in amplitude of P27, over the parietal areas, and of N60 and P100 which also presented abnormal field distributions, being represented preferentially over the frontal regions. These data could suggest the existence of a cortical dysfunction mostly involving the frontal lobes (supplementary motor area, in particular) in the fraX syndrome which could support many behavioral changes usually observed in these patients.