Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer
Safety and efficacy of image-guided enzyme-targeting radiosensitization and intraoperative radiotherapy for locally advanced unresectable pancreatic cancer
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DOI：
10.3892/ol.2014.2101
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发表时间：
2014-07-01
期刊：
影响因子：
2.9
通讯作者：
Hanazaki, Kazuhiro
中科院分区：
文献类型：
--
作者：
Nishioka, Akihito;Ogawa, Yasuhiro;Hanazaki, Kazuhiro
一种新的放射增敏治疗，包括注射过氧化氢和透明质酸钠，使用超声引导，到肿瘤术前立即术中放疗（IORT），建立了IVa期局部晚期不可切除的胰腺癌患者。本研究的目的是评估这种新型治疗方法的安全性和有效性，称为Kochi Oxydol-放射治疗不可切除的癌症-IORT（KORTUC和IORT）。总共有12例患者接受了KORTUC-IORT、外照射放疗和使用盐酸吉西他滨和S-1的全身化疗。为了评价治疗和不良反应，在治疗前以及KORTUC-IORT后1个月和6个月进行了对比增强计算机断层扫描。每月定期随访时进行体检。1年和2年生存率分别为75%和25%，中位生存时间为16个月。所有与KORTUC-IORT相关的治疗患者耐受性良好，不良反应较少，无严重并发症。已确定KORTUC-IORT联合外射束放疗和全身化疗对局部晚期不可切除胰腺癌患者安全有效。
A novel radiosensitization treatment involving the injection of hydrogen peroxide and sodium hyaluronate, using ultrasonic guidance, into a tumor immediately prior to intraoperative radiotherapy (IORT) was established for patients with stage IVa locally advanced unresectable pancreatic cancer. The aim of the present study was to assess the safety and efficacy of this novel treatment, termed Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas-IORT (KORTUC and IORT). In total, 12 patients were treated with KORTUC-IORT, external-beam radiotherapy and systemic chemotherapy using gemcitabine hydrochloride and S-1. For evaluation of the therapeutic and adverse effects, contrast-enhanced computed tomography was conducted prior to the treatment, and one and six months following KORTUC-IORT. Medical examinations were performed every month at the regularly scheduled follow-up visits. The one- and two-year survival rates were 75 and 25%, respectively, and the median survival time was 16 months. All treatments associated with KORTUC-IORT were well-tolerated by the patients, with a small number of adverse effects and no serious complications. It was identified that the delivery of KORTUC-IORT is safe and effective, in combination with external-beam radiotherapy and systemic chemotherapy, for patients with locally advanced unresectable pancreatic cancer.