Potent preclinical sensitivity to imipridone-based combination therapies in oncohistone H3K27M-mutant diffuse intrinsic pontine glioma is associated with induction of the integrated stress response, TRAIL death receptor DR5, reduced ClpX and apoptosis.
Potent preclinical sensitivity to imipridone-based combination therapies in oncohistone H3K27M-mutant diffuse intrinsic pontine glioma is associated with induction of the integrated stress response, TRAIL death receptor DR5, reduced ClpX and apoptosis.
复制标题
癌组蛋白 H3K27M 突变型弥漫性内源性脑桥神经胶质瘤对基于亚咪啶酮的联合疗法的有效临床前敏感性与综合应激反应、TRAIL 死亡受体 DR5、ClpX 减少和细胞凋亡的诱导有关。
DOI：
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发表时间：
2021
影响因子：
5.3
通讯作者：
El-Deiry,WafikS
中科院分区：
文献类型：
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作者：
Borsuk,Robyn;Zhou,Lanlan;Chang,Wen-I;Zhang,Yiqun;Sharma,Aditi;Prabhu,VarunV;Tapinos,Nikos;Lulla,RishiR;El-Deiry,WafikS
