Blood pressure and phosphate level in diabetic and non-diabetic kidney disease: Results of the cross-sectional "Low Clearance Consultation" study.
Blood pressure and phosphate level in diabetic and non-diabetic kidney disease: Results of the cross-sectional "Low Clearance Consultation" study.
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DOI：
10.1016/j.pbj.2017.02.005
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发表时间：
2017-11-01
期刊：
影响因子：
--
通讯作者：
Silva, Gil
中科院分区：
文献类型：
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作者：
Mendes, Margarida;Resende, Luis;Silva, Gil
亮点：在整个样本中，收缩压和血浆磷酸盐浓度之间存在统计学显著性和中度正相关结果显示，在所有受试者中，舒张压与血浆磷酸盐浓度之间均呈中度正相关，且具有统计学意义在糖尿病慢性肾病组中，舒张压与估计的肾小球滤过率之间存在统计学显著和强负相关，但在整个样本（糖尿病和非糖尿病）中没有统计学显著相关性。摘要：糖尿病肾病具有某些不同于其他病因的慢性肾病的临床和实验室特征。我们进行了一项横向研究，比较了这些特征，并评估了糖尿病和非糖尿病慢性肾脏病患者的血压，血浆磷酸盐浓度和估计肾小球滤过率之间的潜在关联，我们发现糖尿病肾病组的收缩压和舒张压与血浆磷酸盐浓度呈正相关，但非糖尿病组不相关。此外，舒张压与估计肾小球滤过率在糖尿病组呈负相关，而不是在non-diabetic group.In结论，这些数据支持的假设之间的密切联系收缩压和舒张压和高磷血症，以及舒张压和估计肾小球滤过率，在糖尿病肾病患者。针对这些因素的治疗方法可能被证明对延缓糖尿病肾病患者亚组的肾功能下降很重要。
HIGHLIGHTS: A statistically significant and moderate positive correlation was verified between systolic blood pressure and plasma phosphate concentration in the whole sample (diabetic and non-diabetic), due to the diabetic chronic kidney disease group.A statistically significant and moderate positive correlation was verified between the diastolic blood pressure and plasma phosphate concentration in the whole sample (diabetic and non-diabetic), due to the diabetic chronic kidney disease group.A statistically significant and strong negative correlation was found between diastolic blood pressure and estimated glomerular filtration rate in the diabetic chronic kidney disease group, but there was no statistically significant correlation in the whole sample (diabetic and non-diabetic).ABSTRACT: Diabetic kidney disease features certain clinical and laboratorial characteristics that differ from chronic kidney disease of other etiologies. We performed a transversal study comparing some of these characteristics and assessed potential associations among blood pressure, plasma phosphate concentration and estimated glomerular filtration rate between patients with diabetic and non-diabetic chronic kidney disease.We found a positive correlation between both systolic and diastolic blood pressure and the plasma phosphate concentration in the diabetic kidney disease group, but not in the non-diabetic group. Also, diastolic blood pressure was negatively correlated with the estimated glomerular filtration rate in the diabetic group, yet not in the non-diabetic group.In conclusion, these data support the hypothesis of a close link between systolic and diastolic blood pressure and hyperphosphatemia, as well as between diastolic blood pressure and estimated glomerular filtration rate, in patients with diabetic kidney disease. Therapeutic approaches directed at these factors might prove to be important to delay the decline of renal function in the subgroup of patients with diabetic kidney disease.