Oxidative stress and lung function.
Oxidative stress and lung function.
复制标题
氧化应激和肺功能。
DOI：
10.1093/oxfordjournals.aje.a009220
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发表时间：
1997
影响因子：
5
通讯作者：
Trevisan,M
中科院分区：
文献类型：
--
作者：
Schünemann,HJ;Muti,P;Freudenheim,JL;Armstrong,D;Browne,R;Klocke,RA;Trevisan,M
研究表明，肺功能可以通过自由基和氧化剂暴露来改变，而抗氧化维生素摄入量与肺功能呈正相关。然而，关于血液中氧化剂和抗氧化剂水平与肺功能的关系的信息很少。本横断面研究于1995年9月至1996年5月进行，分析了肺功能与1秒用力呼气量之间的关系，血浆（p-TBARS）和低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇中硫代巴比妥酸反应物质（FEV 1 + 1）水平（LDL胆固醇/VLDL胆固醇-TBARS）作为脂质过氧化的指标，和2）具有抗氧化活性的化合物、红细胞谷胱甘肽、血浆谷胱甘肽过氧化物酶、trolox当量抗氧化能力和血清胆红素，其可以防止脂质过氧化。从纽约伊利和尼亚加拉两县随机抽取132名年龄在37-73岁的非吸烟者进行分析。FEV 1占预测值的百分比（FEV 1）与p-TBARS呈负相关，且具有统计学显著性（r=-0.19）。FEV1%与低密度脂蛋白胆固醇/极低密度脂蛋白胆固醇-TBARS（r=-0.16）和谷胱甘肽（r=-0.16）呈负相关，具有临界统计学意义，而FEV1%与血清胆红素呈正相关（r= 0.15）。FEV1%最低四分位数的参与者与最高四分位数的参与者相比，p-TBARS水平显著较高（p= 0.02），胆红素水平较低（p= 0.04）。我们的研究结果表明，增加脂质过氧化与肺气道狭窄在一般人群。
It has been suggested that lung function can be altered by both free radical and oxidant exposure, while antioxidant vitamin intake is positively related to lung function. However, the information on the relation of blood levels of oxidants and antioxidants to lung function is sparse. The present cross-sectional study, conducted from September 1995 to May 1996, analyzes the association between lung function measured as forced expiratory volume in 1 second (FEV1with 1) levels of thiobarbituric acid-reactive substances in plasma (p-TBARS) and in low and very low density lipoprotein cholesterol (LDL cholesterol/VLDL cholesterol-TBARS) as indicators of lipid peroxidation and 2) compounds with antioxidant activity, erythrocytic glutathione, plasma glutathione peroxidase, trolox equivalent antioxidant capacity, and serum bilirubin, which may protect against lipid peroxidation. The analysis was carned out in 132 nonsmoking subjects aged 37–73 years who were randomly selected from the residents of Erie and Niagara counties, New York. FEV1in percent of the predicted value (FEV1) was negatively and statistical significantly associated with p-TBARS (r= −0.19). A negative association with borderline statistical significance was observed between FEV1% with low density lipoprotein cholestero/very low density lipoprotein cholesterol-TBARS (r= −0.16) and glutathione (r= −0.16), while FEV1% was positively related to serum bilirubin (r= 0.15). Participants in the lowest quartile of FEV1% showed significantly higher levels of p-TBARS (p= 0.02) and lower levels of bilirubin (p= 0.04) than did those in the highest quartile. Our results suggest that increased lipid peroxidation is associated with pulmonary airway narrowing in the general population.