Dose response for infection by Escherichia coli O157:H7 from outbreak data
Dose response for infection by Escherichia coli O157:H7 from outbreak data
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DOI：
10.1111/j.0272-4332.2004.00441.x
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发表时间：
2004-04-01
期刊：
影响因子：
3.8
通讯作者：
Shinagawa, K
中科院分区：
文献类型：
--
作者：
Teunis, P;Takumi, K;Shinagawa, K
1996年，日本一所小学爆发了与O157：H7有关的大肠杆菌疾病。对IBIS暴发进行了不同寻常的详细研究，使其成为定量风险评估的重要案例。由于可获得受污染食品的储存样本，因此可以可靠地估计接触病原体的情况。收集粪便样本可以评估感染人数，包括无症状病例。与其他已发表的O157：H7大肠杆菌的剂量反应研究相比，这里研究的引起暴发的菌株的传染性肯定要大得多。我们以这一有充分记录的事件为例，说明如何将有关单次剂量反应的信息用于剂量-反应评估。特别是，我们演示了高传染性如何限制低剂量区域的不确定性。
In 1996, an outbreak of E. coli O157:H7-associated illness occurred in an elementary school in Japan. Ibis outbreak has been studied in unusual detail, making this an important case for quantitative risk assessment. The availability of stored samples of the contaminated food allowed reliable estimation of exposure to the pathogens. Collection of fecal samples allowed assessment of the numbers infected, including asymptomatic cases. Comparison to other published dose-response studies for E. coli O157:H7 show that the strain that caused the outbreak studied here must have been considerably more infectious. We use this well-documented incident as an example to demonstrate how such information on the response to a single dose can be used for dose-response assessment. In particular, we demonstrate how the high infectivity limits the uncertainty in the low-dose region.