A critical role of toll-like receptor 2 (TLR2) and its' in vivo ligands in radio-resistance.
A critical role of toll-like receptor 2 (TLR2) and its' in vivo ligands in radio-resistance.
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Toll 样受体 2 (TLR2) 及其体内配体在放射抗性中的关键作用
DOI：
10.1038/srep13004
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发表时间：
2015-08-13
影响因子：
4.6
通讯作者：
Liu C
中科院分区：
文献类型：
--
作者：
Gao F;Zhang C;Zhou C;Sun W;Liu X;Zhang P;Han J;Xian L;Bai D;Liu H;Cheng Y;Li B;Cui J;Cai J;Liu C
Toll样受体2（TLR 2）在放射抗性中的作用尚不清楚。TLR 2敲除（TLR 2-/-）小鼠接受6.5戈伊的辐射，然后进行研究。我们发现，辐射导致TLR 2 −/−小鼠更严重的死亡率和发病率。TLR 2-/-小鼠的死亡原因可能是严重且持续的骨髓细胞丢失。将TLR 2激动剂Pam 3CSK 4注射到野生型（WT）小鼠中诱导了放射抗性。Myd 88 −/−小鼠对辐射更敏感。总之，我们的数据表明，类似于TLR 4，TLR 2在辐射抗性中起着关键作用。
The role of Toll-like receptor-2 (TLR2) in radio-resistance remained largely unknown. TLR2 knockout (TLR2−/−) mice received radiation of 6.5 Gy, and then were studied. We found that radiation resulted in more severe mortality and morbidity rates in TLR2−/− mice. The cause of death in TLR2−/− mice may be severe and persistent bone marrow cell loss. Injection of the TLR2 agonist Pam3CSK4 into wild type (WT) mice induced radio-resistance. Myd88−/− mice were more susceptible to radiation. In conclusion, our data indicate that, similar to TLR4, TLR2 plays a critical role in radio-resistance.