New patterns of diacylglycerol metabolism in intact cells.
New patterns of diacylglycerol metabolism in intact cells.
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完整细胞中二酰甘油代谢的新模式。
DOI：
10.1042/bj2890783
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Rasmussen,H
中科院分区：
文献类型：
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作者：
Florin-Christensen,J;Florin-Christensen,M;Delfino,JM;Rasmussen,H
在四种细胞系中检查了二[1- 14 C]辛酰甘油代谢的代谢：NIH 3 T3成纤维细胞、BHK细胞、Pam 212角质形成细胞和WEHI 3BD+细胞。我们发现1，2-二[1- 14 C]辛酰基-sn-甘油（[14 C] diC 8）直接转化为二辛酰基磷脂酰胆碱和二辛酰基酰基甘油，但没有形成磷脂酰肌醇。[14 C] diC 8也发生脂解分解。相反，1-[1- 14 C]油酰基-2-乙酰基-sn-甘油仅通过脂解代谢。我们的研究结果支持了一个新的计划，代谢终止甘油二酯信号。
The metabolism of di[1-14C]octanoylglycerol metabolism was examined in four cell lines: NIH 3T3 fibroblasts, BHK cells, Pam 212 keratinocytes and WEHI 3BD+ cells. We found the direct conversion of 1,2-di[1-14C]octanoyl-sn-glycerol ([14C]diC8) into dioctanoylphosphatidylcholine and dioctanoylacylglycerol, but no formation of phosphatidylinositol. The [14C]diC8 also underwent lipolytic breakdown. In contrast, 1-[1-14C]oleoyl-2-acetyl-sn-glycerol was metabolized exclusively by lipolysis. Our findings support a new scheme for the metabolic termination of diacylglycerol signals.