Vesicles, capsules and red blood cells under flow
Vesicles, capsules and red blood cells under flow
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流动下的囊泡、胶囊和红细胞
DOI：
10.1088/1742-6596/392/1/012005
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
C. Misbah
中科院分区：
文献类型：
--
作者：
C. Misbah
血流由红细胞 (RBC) 的动态决定，红细胞迄今为止是主要成分。红细胞由二维流体磷脂双层组成，其下方具有赋予其剪切弹性的蛋白质网络，并且它们拥有许多膜和跨膜蛋白质（如离子通道）。简化的系统，如囊泡（由纯磷脂双层制成）和胶囊（由可延伸的聚合物壳制成）被用作红细胞的模型。两个系统都再现了流动下红细胞的几个已知特征。除了一些简单性之外，它们的兴趣还在于它们可以在实验室中制造，并且它们的属性（尺寸、刚度、内部含量……）可以在很大范围内变化，从而可以探索相当重要的参数空间，这对于测试预测和区分不同模型至关重要。我们将回顾该领域最近的主要成就，包括单一实体、集体效应和对流变学的影响。
Blood flow is dictated by the dynamics of red blood cells (RBCs), which constitute by far the major component. RBCs are made of a a two dimensional fluid bilayer of phospholipids, having underneath a network of proteins conferring to them shear elasticity, and they possess many membrane and transmembrane proteins (like ion channels). Simplified systems, like vesicles (made of a pure bilayer of phospholipid) and capsules (made of an extensible polymer shell) are used as models for RBCs. Both systems reproduce several features known for RBCs under flow. Their interest lies, besides some simplicity, in the fact that they can be fabricated in the laboratory, and their properties (size, stiffness, internal content....) can be varied in a wide range allowing thus to explore a quite significant parameter space that is essential to test predictions and discriminate between different models. We shall review the main recent achievement in this field, both for a single entity, collective effects and the impact on rheology.
影响因子：
2.4
作者：
Dupin, Michael M.;Halliday, Ian;Munn, Lance L.
通讯作者：
Munn, Lance L.
影响因子：
3.1
作者：
SECOMB, TW;SKALAK, R
通讯作者：
SKALAK, R
影响因子：
8.6
作者：
Skotheim, J. M.;Secomb, T. W.
通讯作者：
Secomb, T. W.