Associations between depressive symptoms and insulin resistance: The Hoorn Study
Associations between depressive symptoms and insulin resistance: The Hoorn Study
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DOI：
10.1007/s00125-006-0500-4
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发表时间：
2006-12-01
期刊：
影响因子：
8.2
通讯作者：
Pouwer, F.
中科院分区：
文献类型：
--
作者：
Adriaanse, M. C.;Dekker, J. M.;Pouwer, F.
只有少数研究调查了抑郁症和胰岛素抵抗之间的关系，报告的结果相互矛盾。本研究的目的是确定抑郁症状和胰岛素抵抗之间的关系是否因葡萄糖耐量状态和男女而异。研究人员分析了荷兰中型城镇霍恩（Hoorn）一项基于人口的队列研究的横断面数据。研究样本包括541名年龄在55-75岁之间的男性和女性，其中260人患有NGT， 164人患有IGT， 117人患有2型糖尿病。主要结果测量指标为胰岛素抵抗的稳态模型评估（HOMA-IR）和使用流行病学研究中心抑郁量表（CES-D）的抑郁症状。在总样本中，我们发现抑郁症状CED-D评分与HOMA-IR评分之间存在弱正相关（r(s)=0.156, p < 0.001）。NGT患者（r(s)=0.041, p=0.509）、IGT患者（r(s)=0.112, p=0.160）和2型糖尿病患者（r(s)=0.007, p=0.942）的相关性更弱。男性和女性的抑郁症状和胰岛素抵抗之间的关联相似。我们发现抑郁症状和胰岛素抵抗之间只有微弱的联系，这在不同的葡萄糖代谢亚组或男性和女性之间没有差异。
The association between depression and insulin resistance has been investigated in only a few studies, with contradictory results reported. The aim of this study was to determine whether the association between symptoms of depression and insulin resistance varies across glucose tolerance status and between men and women.Cross-sectional data from a population-based cohort study in Hoorn, a medium-sized town in the Netherlands, were analysed. The study sample consisted of 541 men and women aged 55-75 years, of whom 260 had NGT, 164 had IGT and 117 had established type 2 diabetes mellitus. Main outcome measures were insulin resistance defined by the homeostasis model assessment for insulin resistance (HOMA-IR) and symptoms of depression using the Centre for Epidemiologic Studies Depression Scale (CES-D).In the total sample, we found a weak positive correlation between the depressive symptoms CED-D scores and HOMA-IR scores (r(s)=0.156, p < 0.001). Even weaker associations were found in subjects with NGT (r(s)=0.041, p=0.509), in subjects with IGT (r(s)=0.112, p=0.160) and in subjects with type 2 diabetes (r(s)=0.007, p=0.942). The association between depressive symptoms and insulin resistance was similar for men and women.We found only weak associations between depressive symptoms and insulin resistance, which did not differ among different glucose metabolism subgroups or between men and women.