2,3,7,8-Tetrachlorodibenzo-p-dioxin-inducible aryl hydrocarbon receptor-mediated change in CYP1A1 chromatin structure occurs independently of transcription.
2,3,7,8-Tetrachlorodibenzo-p-dioxin-inducible aryl hydrocarbon receptor-mediated change in CYP1A1 chromatin structure occurs independently of transcription.
复制标题
2,3,7,8-四氯二苯并-对二恶英诱导型芳烃受体介导的 CYP1A1 染色质结构变化独立于转录而发生。
DOI：
10.1128/mcb.9.12.5733-5737.1989
复制
发表时间：
1989
影响因子：
5.3
通讯作者：
WhitlockJr,JP
中科院分区：
文献类型：
--
作者：
Durrin,LK;WhitlockJr,JP
2,3,7,8-四氯二苯并-p-二恶英以受体依赖性方式诱导 CYP1A1 染色质对限制性核酸内切酶的可及性增加。 2,3,7,8-四氯二苯并-对二恶英诱导的染色质结构变化迅速发生，不需要持续的 RNA 或蛋白质合成。染色质 DNA 的可及性增加可能有助于其随后与其他转录因子的相互作用。
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces, in a receptor-dependent fashion, an increase in the accessibility ofCYP1A1chromatin to restriction endonucleases. The 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced change in chromatin structure occurs rapidly and does not require ongoing RNA or protein synthesis. The increased accessibility of chromatin DNA may facilitate its subsequent interaction with other transcription factors.