The Phytophthora cactorum genome provides insights into the adaptation to host defense compounds and fungicides.
The Phytophthora cactorum genome provides insights into the adaptation to host defense compounds and fungicides.
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疫霉基因组提供了对宿主防御化合物和杀菌剂的适应的见解
DOI：
10.1038/s41598-018-24939-2
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发表时间：
2018-04-25
影响因子：
4.6
通讯作者：
Zhu S
中科院分区：
文献类型：
--
作者：
Yang M;Duan S;Mei X;Huang H;Chen W;Liu Y;Guo C;Yang T;Wei W;Liu X;He X;Dong Y;Zhu S
恶疫霉是一种同宗配合的卵菌病原菌，其寄主范围广，对寄主防御物质和杀菌剂的适应能力强。本文报道了该菌121.5Mb的基因组组装。cactorum使用第三代单分子实时（SMRT）测序技术。它是迄今为止在Phytophthoragenera中测序的第二大基因组，包含27，981个蛋白质编码基因。与其它植物染色体组比较表明，P. cactorum与P. parasitica、P. infestans和P.与其他卵菌物种相比，P. cactorum在次级代谢和致病相关效应蛋白基因家族上具有相似性，但与解毒酶和碳水化合物活性酶（CAZymes）相关的特异基因家族在P.与窄寄主病原菌P. cactorum相比，P. cactorum对三七中的一组防御化合物--皂苷的利用和解毒能力更强。sojae另外，多糖诱导的解毒酶和水解酶活性相关基因表达水平的升高进一步支持了多糖的高解毒和利用能力。仙人掌素在病原体对宿主植物防御化合物和杀真菌剂的快速适应性中起关键作用。
Phytophthora cactorumis a homothallic oomycete pathogen, which has a wide host range and high capability to adapt to host defense compounds and fungicides. Here we report the 121.5 Mb genome assembly of theP. cactorumusing the third-generation single-molecule real-time (SMRT) sequencing technology. It is the second largest genome sequenced so far in thePhytophthoragenera, which contains 27,981 protein-coding genes. Comparison with otherPhytophthoragenomes showed thatP. cactorumhad a closer relationship withP. parasitica,P. infestansandP. capsici.P. cactorumhas similar gene families in the secondary metabolism and pathogenicity-related effector proteins compared with other oomycete species, but specific gene families associated with detoxification enzymes and carbohydrate-active enzymes (CAZymes) underwent expansion inP. cactorum.P. cactorumhad a higher utilization and detoxification ability against ginsenosides–a group of defense compounds fromPanax notoginseng–compared with the narrow host pathogenP. sojae. The elevated expression levels of detoxification enzymes and hydrolase activity-associated genes after exposure to ginsenosides further supported that the high detoxification and utilization ability ofP. cactorumplay a crucial role in the rapid adaptability of the pathogen to host plant defense compounds and fungicides.
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影响因子：
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作者：
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