Serum perfluoroalkyl substances and breast cancer risk in Japanese women: A case-control study
Serum perfluoroalkyl substances and breast cancer risk in Japanese women: A case-control study
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DOI：
10.1016/j.scitotenv.2021.149316
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发表时间：
2021-08-16
影响因子：
9.8
通讯作者：
Iwasaki, Motoki
中科院分区：
文献类型：
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作者：
Itoh, Hiroaki;Harada, Kouji H.;Iwasaki, Motoki
背景资料：全氟烷基物质（PFASs）可能导致乳腺癌;然而，暴露于PFASs和乳腺癌风险之间的关联是有争议的。目的：在本研究中，我们新区分了PFAS的支链异构体与其线性异构体，旨在研究日本女性血清PFAS浓度与乳腺癌风险之间的关系。研究方法：我们采用病例对照设计，研究了2001年5月至2005年9月在日本长野县四家医院就诊的405对符合条件的配对。我们使用端口芳基化气相色谱质谱负化学电离法测定血清中20 PFAS同系物的浓度。我们通过血清PFAS的四分位数或三分位数计算了乳腺癌及其受体亚型的多变量校正比值比（OR）和95%置信区间（CI）。结果如下：在对乳腺癌危险因素进行多变量校正后，我们发现20种PFAS同系物的血清浓度与乳腺癌风险呈显著负相关。比较全氟辛烷磺酸或全氟辛酸的线性异构体的极端四分位数，OR为0.15（95% CI：0.07，0.33 P趋势
Background: Perfluoroalkyl substances (PFASs) may contribute to causing breast cancer; however, associations between exposure to PFASs and risk of breast cancer are controversial. Objectives: In the present study, we newly distinguished branched isomers of PFASs from their linear isomers and aimed to investigate the association between serum PFAS concentrations and breast cancer risk in Japanese women. Methods: We used a case-control design to study 405 eligible matched pairs attending four hospitals in Nagano Prefecture, Japan from May 2001 to September 2005. We used in-port arylation gas-chromatography mass spectrometry with negative chemical ionization to measure serum concentrations of 20 PFAS congeners. We calculated multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of breast cancer and its hormone-receptor subtypes by quartiles or tertiles of serum PFASs. Results: After multivariable adjustment for breast cancer risk factors, we found that serum concentrations of 20 PFAS congeners were significantly inversely associated with risk of breast cancer. Comparing the extreme quartiles of linear isomers of perfluorooctane sulfonate or perfluorooctanoic acid, ORs were 0.15 (95% CI: 0.07, 0.33 P for trend