Toxicity of methoxyacetic acid in rats.
Toxicity of methoxyacetic acid in rats.
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DOI：
10.1016/s0272-0590(82)80039-0
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发表时间：
1982-07-01
期刊：
影响因子：
--
通讯作者：
McKenna, M J
中科院分区：
文献类型：
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作者：
Miller, R R;Carreon, R E;McKenna, M J
雄性Fischer 344大鼠通过灌胃给予8次0、30、100或300 mg/kg甲氧基乙酸，每日一次。高剂量导致体重下降、睾丸生殖上皮重度变性、胸腺大小减小伴胸腺皮质淋巴样元素耗竭以及骨髓细胞构成减少，导致红细胞计数、血红蛋白浓度、红细胞压积和白色细胞计数下降。其中一些观察结果在100 mg/kg剂量组大鼠中较明显。在研究过程中，低剂量未产生明显影响。甲氧基乙酸的这些毒理学性质与乙二醇单甲醚（EGME）非常相似，EGME在大鼠中的不良反应可能是EGME在体内生物活化为甲氧基乙酸的结果。
Male Fischer 344 rats were given eight daily doses of 0, 30, 100 or 300 mg/kg methoxyacetic acid by gavage. The high dose resulted in decreased body weight, severe degeneration of testicular germinal epithelium, decreased size of the thymus with depletion of thymic cortical lymphoid elements, and reductions in bone marrow cellularity resulting in depressions of red blood cell counts, hemoglobin concentration, packed cell volume, and white blood cell counts. Some of these observations were apparent to a lesser degree in rats given 100 mg/kg. The low dose produced no apparent effects during the course of the study. These toxicological properties of methoxyacetic acid are remarkably similar to ethylene glycol monomethyl ether (EGME), and the adverse effects of EGME in rats are probably the result of in vivo bioactivation of EGME to methoxyacetic acid.