Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury
Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury
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DOI：
10.1016/j.bbrc.2008.05.165
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发表时间：
2008-08-15
影响因子：
3.1
通讯作者：
Fukuda, Keiichi
中科院分区：
文献类型：
--
作者：
Hayashida, Kentaro;Sano, Motoaki;Fukuda, Keiichi
研究表明，吸入氢(H-2)气体可以减少啮齿类动物脑和肝脏的缺血再灌注损伤，从而限制脑和肝脏的梗塞体积。当转化为临床实践时，这种疗法必须最常应用于急性心肌梗死患者的治疗，因为与梗塞相关的闭塞冠状动脉的血管成形性再通是常规操作。因此，我们研究了H-2气体对大鼠心肌缺血再灌注损伤的保护作用。在离体灌流心中，H-2气体可促进缺氧-复氧后左心功能的恢复。吸入的H-2气体被迅速输送，在闭塞的梗塞相关动脉的冠脉血流重建之前，可以到达“危险”的缺血心肌。在缺血和再灌流期间吸入不可燃水平的H-2气体可在不改变血流动力学参数的情况下缩小梗塞面积，从而防止有害的左心室重构。因此，吸入H-2气体是减轻冠脉再通同时减轻缺血再灌注损伤的有效策略。(C)2008 Elsevier Inc.保留所有权利。
Inhalation of hydrogen (H-2) gas has been demonstrated to limit the infarct volume of brain and liver by reducing ischemia-reperfusion injury in rodents. When translated into clinical practice, this therapy must be most frequently applied in the treatment of patients with acute myocardial infarction, since angioplastic recanalization of infarct-related occluded coronary artery is routinely performed. Therefore, we investigate whether H-2 gas confers cardioprotection against ischemia-reperfusion injury in rats. In isolated perfused hearts, H-2 gas enhances the recovery of left ventricular function following anoxia-reoxygenation. Inhaled H-2 gas is rapidly transported and can reach 'at risk' ischemic myocardium before coronary blood flow of the occluded infarct-related artery is reestablished. Inhalation of H-2 gas at incombustible levels during ischemia and reperfusion reduces infarct size without altering hemodynamic parameters, thereby preventing deleterious left ventricular remodeling. Thus, inhalation of H-2 gas is promising strategy to alleviate ischemia-reperfusion injury coincident with recanalization of coronary artery. (C) 2008 Elsevier Inc. All rights reserved.