Causes of Death in HIV-infected Persons Who Have Tuberculosis, Thailand
Causes of Death in HIV-infected Persons Who Have Tuberculosis, Thailand
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DOI：
10.3201/eid1502.080942
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发表时间：
2009-02-01
影响因子：
11.8
通讯作者：
Varma, Jay K.
中科院分区：
文献类型：
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作者：
Cain, Kevin P.;Anekthananon, Thanomsak;Varma, Jay K.
在泰国，高达50%的艾滋病毒感染者和结核病诊断者在结核病治疗期间死亡。在一项前瞻性的观察性研究中，一组医生在审查了口头尸检（对家庭成员关于死亡前事件的采访），实验室数据和医疗记录后，确定了死亡原因。在849名艾滋病毒感染的结核病患者中，142人（17%）死亡。死亡原因是结核病38例（27%），包括6例耐多药结核病和20例播散性结核病;艾滋病毒相关疾病50例（35%），而非结核病;与结核病或艾滋病毒无关的疾病22例（15%）。23名患者（16%）被判定为根本没有结核病。在接受抗逆转录病毒治疗的人中，除与结核病或艾滋病毒无关的原因外，其他原因造成的死亡不太常见。除了增加抗逆转录病毒疗法的使用外，还可通过扩大使用现代结核病诊断技术来降低死亡率。
Up to 50% of persons with HIV and a diagnosis of tuberculosis (TB) in Thailand die during TB treatment. In a prospective observational study, a team of physicians ascribed the cause of death after reviewing verbal autopsies (interviews of family members about events preceding death), laboratory data, and medical records. Of 849 HIV-infected TB patients enrolled, 142 (17%) died. The cause of death was TB for 38 (27%), including 6 with multidrug-resistant TB and 20 with disseminated TB; an HIV-associated condition other than TB for 50 (35%); and a condition unrelated to TB or HIV for 22 (15%). Twenty-three patients (16%) were judged not to have had TB at all. Death from all causes except those unrelated to TB or HIV was less common in persons receiving antiretroviral therapy (ART). In addition to increasing the use of ART, death rates may be reduced through expanded use of modern TB diagnostic techniques.