Involvement of cholangiocyte proliferation in biliary fibrosis.
Involvement of cholangiocyte proliferation in biliary fibrosis.
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DOI：
10.4291/wjgp.v1.i2.30
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发表时间：
2010-06-15
期刊：
影响因子：
--
通讯作者：
Glaser, Shannon S
中科院分区：
文献类型：
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作者：
Priester, Sally;Wise, Candace;Glaser, Shannon S
胆管细胞是排列在胆管树上的上皮细胞。在成人肝脏中，它们是有丝分裂休眠的细胞群，除非损伤引发导管反应。胆管细胞的增殖能力在许多针对这种细胞类型的不同人类病理性肝脏疾病中非常重要，这些疾病被称为胆管病（即原发性胆汁性肝硬化、原发性硬化性胆管炎和胆道闭锁）。在我们的文章中，我们提供了有关胆管细胞形态和功能异质性的背景信息，总结了目前对其增殖过程的了解，并简要描述了针对这些细胞的疾病。此外，我们还讨论了最近的研究结果，表明胆管细胞参与上皮间质转化和肝纤维化，并提出了未来的研究方向。
Cholangiocytes are the epithelial cells that line the biliary tree. In the adult liver, they are a mitotically dormant cell population, unless ductular reaction is triggered by injury. The ability of cholangiocytes to proliferate is important in many different human pathological liver conditions that target this cell type, which are termed cholangiopathies (i.e. primary biliary cirrhosis, primary sclerosing cholangitis and biliary atresia). In our article, we provide background information on the morphological and functional heterogeneity of cholangiocytes, summarize what is currently known about their proliferative processes, and briefly describe the diseases that target these cells. In addition, we address recent findings that suggest cholangiocyte involvement in epithelial-to-mesenchymal transformation and liver fibrosis, and propose directions for future studies.