The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
复制标题
DOI：
10.1038/nm1095
复制
发表时间：
2004-09-01
期刊：
影响因子：
82.9
通讯作者：
Muñoz, A
中科院分区：
文献类型：
--
作者：
Pálmer, HG;Larriba, MJ;Muñoz, A
Please try later.
Several non-hypercalcemic analogs of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)(2)D-3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognosis but is lost during tumor progression. We show that the SNAIL transcription factor represses VDR gene expression in human colon cancer cells and blocks the antitumor action of EB1089, a 1,25(OH)(2)D-3 analog, in xenografted mice. In human colon cancers, elevated SNAIL expression correlates with downregulation of VDR.