ALPHA1-ANTITRYPSIN AN INHIBITOR FOR THROMBIN AND PLASMIN
ALPHA1-ANTITRYPSIN AN INHIBITOR FOR THROMBIN AND PLASMIN
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DOI：
10.1016/0009-8981(67)90104-0
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发表时间：
1967-01-01
影响因子：
5
通讯作者：
TAN, BH
中科院分区：
文献类型：
--
作者：
GANS, H;TAN, BH
对两名患有严重肺气肿和纯合型抗胰蛋白酶缺乏症的患者的[α] 1-抗胰蛋白酶缺乏型血浆进行了凝血酶和纤溶酶中和能力测试。与正常的去乙酰化血浆相反，[α]1-抗胰蛋白酶缺乏的血浆缺乏快速抗凝血酶凝血活性。剩余的抗凝血活性是缓慢的、渐进的，约占正常血浆总抗凝血酶抗凝血活性的20-25%。这一发现表明，[α] 1-抗凝血酶是一种快速抗凝血酶，其代表了至少75%的这种类型的血液抗凝活性。这也表明它可能与[α]1-抗胰蛋白酶相同。相比之下，[α]1-抗胰蛋白酶缺乏的血浆具有与正常血浆相同的凝血酶酯酶抑制活性。然而，快速抗纤溶酶浓度在[α]1-抗胰蛋白酶缺乏的血浆中降低了约50%。这些发现与[α]1-抗胰蛋白酶代表一种抗蛋白酶的概念一致，其活性范围比其名称所暗示的范围更广。
[alpha] 1-Antitrypsin- deficient plasma of two patients with severe pulmonary emphysema and homozygous ari-antitrypsin deficiency was tested for its thrombin- and plasmin-neutralizing capacities. In contrast to normal, defibrinated plasma, [alpha]1-antitrypsin-deficient plasma lacks fast antithrombin clotting activity. The anticoagulant activity which remains is of the slow, progressive variety and constitutes approximately 20-25% of the total antithrombin anticoagulant activity of normal plasma. This finding indicates that [alpha] 1-anti-thrombin is a fast antithrombin which represents at least 75% of this type of anticoagulant activity of blood. It also suggests that it is probably identical with [alpha]1-antitrypsin. In contrast, [alpha]1-antitrypsin-deficient plasma has the same thrombin esterase-inhibiting activity as normal plasma. Fast antiplasmin concentrations, however, were reduced by approximately 50% in [alpha]1-antitrypsin-deficient plasma. These findings are consistent with the concept that [alpha]1-antitrypsin represents an antiproteinase with a wider range of activity than its name would suggest.