Association Between Pathophysiological Mechanisms of Diabetic Retinopathy and Parkinson's Disease
Association Between Pathophysiological Mechanisms of Diabetic Retinopathy and Parkinson's Disease
复制标题
糖尿病视网膜病变与帕金森病的病理生理机制之间的关联
DOI：
10.1007/s10571-020-00953-9
复制
发表时间：
2020
影响因子：
4
通讯作者：
Yang Xiaochun
中科院分区：
文献类型：
--
作者：
Zhang Zhuoqing;Zhou Yikun;Zhao Haiyan;Xu Jinghui;Yang Xiaochun
糖尿病视网膜病变是一种眼部神经退行性疾病，是糖尿病最常见的并发症。帕金森氏症是第二大大脑神经退行性疾病，影响着全世界1-2%的60岁以上老年人的健康。随着人们对糖尿病视网膜病变和帕金森病认识的加深，发现两者在发病率上具有相关性，在临床表现上具有相似性，在病理生理机制上有着密切的联系。为了揭示两种疾病的病理生理机制之间的联系，本文将糖尿病视网膜病变和帕金森病的共同病理生理因素归纳为多巴胺能系统、昼夜节律、神经营养因子、α-突触核蛋白和Wnt信号通路。此外，系统地讨论了两种疾病的相似和不同机制以及共同的病理生理因素。最后，简要总结并提出新的观点，为进一步开展糖尿病视网膜病变与帕金森病的关联、探索及临床防治提供新的方向。
Diabetic retinopathy, the most common complication of diabetes, is a neurodegenerative disease in the eye. And Parkinson's disease, affecting the health of 1–2% of people over 60 years old throughout the world, is the second largest neurodegenerative disease in the brain. As the understanding of diabetic retinopathy and Parkinson's disease deepens, the two diseases are found to show correlation in incidence, similarity in clinical presentation, and close association in pathophysiological mechanisms. To reveal the association between pathophysiological mechanisms of the two disease, in this review, the shared pathophysiological factors of diabetic retinopathy and Parkinson's disease are summarized and classified into dopaminergic system, circadian rhythm, neurotrophic factors, α-synuclein, and Wnt signaling pathways. Furthermore, similar and different mechanisms so far as the shared pathophysiological factors of the two disorders are discussed systematically. Finally, a brief summary and new perspectives are presented to provide new directions for further efforts on the association, exploration, and clinical prevention and treatment of diabetic retinopathy and Parkinson's disease.