SONIC HEDGEHOG INDUCES THE DIFFERENTIATION OF VENTRAL FOREBRAIN NEURONS - A COMMON SIGNAL FOR VENTRAL PATTERNING WITHIN THE NEURAL-TUBE
SONIC HEDGEHOG INDUCES THE DIFFERENTIATION OF VENTRAL FOREBRAIN NEURONS - A COMMON SIGNAL FOR VENTRAL PATTERNING WITHIN THE NEURAL-TUBE
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DOI：
10.1016/0092-8674(95)90536-7
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发表时间：
1995-06-02
期刊：
影响因子：
64.5
通讯作者：
EDLUND, T
中科院分区：
文献类型：
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作者：
ERICSON, J;MUHR, J;EDLUND, T
脊椎动物刺猬相关基因Sonic hedgehog(Shh)在包括前脑在内的神经管的整个吻尾长度的腹侧区域都有表达。我们在这里展示了SHH在神经板的预期前脑区的外植体中诱导腹侧神经细胞类型的分化。来源于神经板间脑和端脑水平的外植体诱导的神经元表达LIM同源结构域蛋白ISL-1，这些神经元具有与活体前脑这两个亚区产生的腹侧神经元不同的特征。因此，一个单一的诱导分子SHH似乎介导了沿着整个胚胎中枢神经系统喙尾侧的不同类型的腹神经细胞的诱导。
The vertebrate hedgehog-related gene Sonic hedgehog (Shh) is expressed in ventral domains along the entire rostrocaudal length of the neural tube, including the forebrain. We show here that SHH induces the differentiation of ventral neuronal cell types in explants derived from prospective forebrain regions of the neural plate. Neurons induced in explants derived from both diencephalic and telencephalic levels of the neural plate express the LIM homeodomain protein Isl-1, and these neurons possess distinct identities that match those of the ventral neurons generated in these two subdivisions of the forebrain in vivo. A single inducing molecule, SHH, therefore appears to mediate the induction of distinct ventral neuronal cell types along the entire rostrocaudal extent of the embryonic central nervous system.