Sensory cognitive abnormalities of pain in autism spectrum disorder: a case-control study.
Sensory cognitive abnormalities of pain in autism spectrum disorder: a case-control study.
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DOI：
10.1186/s12991-016-0095-1
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发表时间：
2016
影响因子：
3.7
通讯作者：
Takeda M
中科院分区：
文献类型：
--
作者：
Yasuda Y;Hashimoto R;Nakae A;Kang H;Ohi K;Yamamori H;Fujimoto M;Hagihira S;Takeda M
精神障碍诊断和统计手册，第5版（DSM-5）最近将感觉处理异常纳入自闭症谱系障碍（ASD）个体的诊断标准。然而，没有标准的方法来评估ASD患者的感觉异常。15名ASD患者和15名年龄和性别匹配的对照者参加了这项研究。我们通过测量对三种不同刺激（电、热和冷）的疼痛检测阈值和疼痛耐受性来比较客观疼痛敏感性。然后，我们比较了主观疼痛敏感性（通过视觉模拟量表（VAS）评估）和疼痛质量（通过简易麦吉尔疼痛问卷（SF-MPQ）评估），以确定每种刺激的最大可耐受疼痛强度。ASD患者的疼痛检测阈值和疼痛耐受性没有受损，表明各组之间的疼痛躯体感知没有差异。然而，与对照组相比，ASD患者对主观疼痛强度低敏（VAS;电：p = 0.044，冷：p = 0.011，热：p = 0.042），对疼痛敏感性的情感方面低敏（SF-MPQ;电：p = 0.0071，冷：p = 0.042）。我们的研究结果表明，疼痛处理的认知通路受损的ASD，此外，我们的方法可用于评估疼痛敏感性的个体与ASD。需要进一步调查ASD患者的感觉异常，以澄清可能改变这种疾病的感觉处理的病理生理过程。
The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) recently included sensory processing abnormalities in the diagnostic criteria for individuals with autism spectrum disorder (ASD). However, there is no standard method for evaluating sensory abnormalities in individuals with ASD. Fifteen individuals with ASD and 15 age- and sex-matched controls were enrolled in this study. We compared objective pain sensitivity by measuring the pain detection threshold and pain tolerance to three different stimuli (electricity, heat, and cold). Then, we compared both subjective pain sensitivity, assessed by the visual analog scale (VAS), and quality of pain, assessed by the short-form McGill Pain Questionnaire (SF-MPQ), to determine the maximum tolerable pain intensities of each stimulation. The pain detection threshold and pain tolerance of individuals with ASD were not impaired, indicating that there were no differences in the somatic perception of pain between groups. However, individuals with ASD were hyposensitive to subjective pain intensity compared to controls (VAS; electrical: p = 0.044, cold: p = 0.011, heat: p = 0.042) and hyposensitive to affective aspects of pain sensitivity (SF-MPQ; electrical: p = 0.0071, cold: p = 0.042). Our results suggest that the cognitive pathways for pain processing are impaired in ASD and, furthermore, that our methodology can be used to assess pain sensitivity in individuals with ASD. Further investigations into sensory abnormalities in individuals with ASD are needed to clarify the pathophysiologic processes that may alter sensory processing in this disorder.