The Histone Variant H3.3 in Transcriptional Regulation and Human Disease.
The Histone Variant H3.3 in Transcriptional Regulation and Human Disease.
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DOI：
10.1016/j.jmb.2016.11.019
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发表时间：
2017-06-30
影响因子：
5.6
通讯作者：
Shi X
中科院分区：
文献类型：
--
作者：
Shi L;Wen H;Shi X
组蛋白包裹 DNA 形成核小体，核小体进一步压缩成染色质的高级结构。除了经典组蛋白之外，还有一些变异组蛋白，它们通常在调节染色质动力学和底层 DNA 的可及性方面发挥着关键作用。 H3.3 是组蛋白 H3 最常见的非着丝粒变体，与经典 H3 仅 4-5 个氨基酸不同。在这里我们讨论H3.3在转录调控方面的最新知识以及H3.3突变在人类癌症中的最新发现和分子机制。
Histone proteins wrap around DNA to form nucleosomes, which further compact into higher order structure of chromatin. In addition to the canonical histones, there are also variant histones that often have pivotal roles in regulating chromatin dynamics and the accessibility of the underlying DNA. H3.3 is the most common non-centromeric variant of histone H3 that differs from the canonical H3 by just 4–5 amino acids. Here we discuss the current knowledge of H3.3 in transcriptional regulation and the recent discoveries and molecular mechanisms of H3.3 mutations in human cancer.