Evolution of simple sequence repeat-mediated phase variation in bacterial genomes
Evolution of simple sequence repeat-mediated phase variation in bacterial genomes
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DOI：
10.1111/j.1749-6632.2012.06584.x
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Palmer, Michael E.
中科院分区：
文献类型：
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作者：
Bayliss, Christopher D.;Palmer, Michael E.
突变作为快速适应环境挑战的机制是一个非常简单的概念，其典范是在简单序列重复（SSR）中实现的。几个物种的细菌基因组含有SSR，其在适应环境波动方面的作用已得到证实。SSR是超变的，在细菌基因组的局部区域产生可逆突变，导致基因表达中的相位可变ON/OFF开关。遗传学、生物信息学和数学/计算建模方法的应用正在彻底改变我们目前对基因组分子力和环境因素如何影响SSR介导的适应的理解，并导致细菌基因组中局部超突变机制的进化。
Mutability as mechanism for rapid adaptation to environmental challenge is an alluringly simple concept whose apotheosis is realized in simple sequence repeats (SSR). Bacterial genomes of several species contain SSRs with a proven role in adaptation to environmental fluctuations. SSRs are hypermutable and generate reversible mutations in localized regions of bacterial genomes, leading to phase variable ON/OFF switches in gene expression. The application of genetic, bioinformatic, and mathematical/computational modeling approaches are revolutionizing our current understanding of how genomic molecular forces and environmental factors influence SSR-mediated adaptation and led to evolution of this mechanism of localized hypermutation in bacterial genomes.