The Toxicity of Aluminum Chloride on Kidney of Rats
The Toxicity of Aluminum Chloride on Kidney of Rats
复制标题
氯化铝对大鼠肾脏的毒性
DOI：
10.1007/s12011-016-0648-9
复制
发表时间：
2016-10-01
影响因子：
3.9
通讯作者：
Li, Yanfei
中科院分区：
文献类型：
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作者：
Liu, Jianyu;Wang, Qin;Li, Yanfei
本研究探讨了氯化铝(AlCl3)对大鼠肾脏的毒性作用。40只5周龄雄性Wistar大鼠，体重110~120g，随机分为4组：对照组(CG，0g/L AlCl3)、低剂量组(LG，0.4g/L AlCl3)、中剂量组(MG，0.8g/L AlCl3)和高剂量组(HG，1.6g/L AlCl3)。大鼠饮水中加入三氯化铝，连续120天。测定超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-P-X)活性、肾脏丙二醛(MDA)浓度、血尿素氮(BUN)和血清胱抑素C(Cys-C)浓度。测定尿铝和β(2)-微球蛋白(β(2)-MG)浓度及尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)活性。结果表明，与对照组相比，AlCl3处理组大鼠肝组织中SOD、GSH-P-X活性降低，NAG活性升高，Al、MDA、BUN、Cys-C和β(2)-MG含量升高。这项研究表明，接触AlCl3会导致氧化应激，抑制肾功能。
This study investigated the toxicity of aluminum chloride (AlCl3) exposure in the rat kidney. Forty male Wistar rats (5 weeks old), weighing 110-120 g, were randomly divided into four groups: control group (CG, 0 g/L AlCl3), low dose group (LG, 0.4 g/L AlCl3), mid dose group (MG, 0.8 g/L AlCl3), and high dose group (HG, 1.6 g/L AlCl3). Rats were administered AlCl3 in their drinking water for 120 days. A variety of measurements were taken including superoxide dismutase (SOD) and glutathione peroxidase (GSH-P-X) activities, malondialdehyde (MDA) concentration in the kidney and blood urea nitrogen (BUN), and cystatin C (Cys-C) concentrations in the serum. In addition, Al and beta(2)-microglobulin (beta(2)-MG) concentrations and the activity of N-acetyl-beta-d-glucosaminidase (NAG) in the urine were determined. The results showed that in the AlCl3-treated groups SOD and GSH-P-X activities were decreased, while NAG activity and Al, MDA, BUN, Cys-C, and beta(2)-MG concentrations were increased, compared with the CG. This study indicates that AlCl3 exposure induces oxidative stress and suppresses kidney function.