Brain oxygenation and metabolism during repetitive apnea with resuscitation of 21% and 100% oxygen in newborn piglets.
Brain oxygenation and metabolism during repetitive apnea with resuscitation of 21% and 100% oxygen in newborn piglets.
复制标题
脑%20氧合%20和%20代谢%20期间%20重复%20呼吸暂停%20和%20复苏%20的%2021%%20和%20100%%20氧%20in%20新生儿%20仔猪。
DOI：
10.1007/s11064-005-8655-9
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发表时间：
2005
影响因子：
4.4
通讯作者：
Pastuszko,Anna
中科院分区：
文献类型：
--
作者：
Schears,Gregory;Antoni,Diego;Schultz,Steven;Zaitseva,Tatiana;Greeley,William;Wilson,DavidF;Pastuszko,Anna
在反复呼吸暂停和复苏期间用 21% 或 100% 氧气测定仔猪大脑微循环中的氧气分布和纹状体细胞外多巴胺。呼吸暂停前皮质氧为 49.5 ± 10.4 mm Hg，每次呼吸暂停期间下降至 8 ± 0.9 mm Hg。十次呼吸暂停发作后，用 21% 或 100% 氧气进行复苏，分别有 7.48 ± 1.6% 或 2.6 ± 0.5% 的组织体积低于 10 mm Hg。随着 21% 氧气复苏时呼吸暂停次数的增加，细胞外多巴胺逐渐增加，在 10 次呼吸暂停发作结束时，其达到对照的 59,500 ± 11,320%。在 100% 氧气复苏呼吸暂停期间，细胞外多巴胺没有增加。重复性呼吸暂停导致新生儿缺氧脑组织比例逐渐增加。增加的幅度取决于动物是否使用室内空气或 100% 氧气进行复苏。
The oxygen distribution in the microcirculation of the piglet’s brain and striatal extracellular dopamine were determined during repetitive apnea and resuscitation with 21% or 100% oxygen. Pre-apnea cortical oxygen was 49.5 ± 10.4 mm Hg and during each apnea decreased to 8 ± 0.9 mm Hg. After ten apneic episodes followed by resuscitation with 21% or 100% oxygen, 7.48 ± 1.6% or 2.6 ± 0.5% of the tissue volume was below 10 mm Hg, respectively. Extracellular dopamine increased progressively with an increase in the number of apneas with resuscitation of 21% oxygen and at the end of ten apneic episodes it was up to 59,500 ± 11,320% of control. There was no increase in extracellular dopamine during apnea resuscitated with 100% oxygen. Repetitive apnea caused progressive increase in fraction of hypoxic brain tissue in newborn. The magnitude of the increase is dependent on whether the animals were resuscitated with room air or 100% oxygen.