LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process
LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process
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LSD1 通过维持 HIF1 α 依赖性糖酵解过程维持胰腺癌生长
DOI：
10.1016/j.canlet.2014.02.013
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发表时间：
2014-06-01
期刊：
影响因子：
9.7
通讯作者：
Yu, Xianjun
中科院分区：
文献类型：
--
作者：
Qin, Yi;Zhu, Wenwei;Yu, Xianjun
组蛋白去甲基化酶LSD 1（lysine specific demethylase 1）在基因转录的表观遗传调控中起重要作用。我们的研究调查了LSD 1在胰腺癌中的作用，并证明LSD 1在胰腺癌患者组织样本中显著上调，LSD 1蛋白水平升高与胰腺癌患者的总生存率呈正相关。使用体外和体内模型，我们证明了LSD 1的敲低抑制胰腺癌细胞的增殖和致瘤性。从机制上讲，我们的研究表明LSD 1与HIFI a（缺氧诱导因子-1 α）协同维持糖酵解过程，这促进了胰腺癌不受控制的增殖。(C)2014爱思唯尔爱尔兰有限公司版权所有。
The histone demethylase LSD1 (lysine specific demethylase 1) plays an important role in the epigenetic regulation of gene transcription. Our study investigated the role of LSD1 in pancreatic cancer and demonstrated that LSD1 was significantly up-regulated in pancreatic cancer patient tissue samples, and elevated LSD1 protein levels positively correlated with overall survival of pancreatic cancer patients. Using in vitro and in vivo models, we demonstrated that knock-down of LSD1 repressed proliferation and tumorigenicity of pancreatic cancer cells. Mechanistically, our study demonstrated that LSD1 synergized with HIFI a (hypoxia inducible factor-1 alpha) in maintaining glycolytic process, which fueled pancreatic cancer uncontrolled proliferation. (C) 2014 Elsevier Ireland Ltd. All rights reserved.