PROLONGED QT, ATRIOVENTRICULAR-BLOCK, AND SUDDEN-DEATH IN THE NEWBORN - AN ELECTROPHYSIOLOGIC EVALUATION
PROLONGED QT, ATRIOVENTRICULAR-BLOCK, AND SUDDEN-DEATH IN THE NEWBORN - AN ELECTROPHYSIOLOGIC EVALUATION
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DOI：
10.1093/eurheartj/12.7.838
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发表时间：
1991-07-01
影响因子：
39.3
通讯作者：
TOUBOUL, P
中科院分区：
文献类型：
--
作者：
SAOUDI, N;BOZIO, A;TOUBOUL, P
在出生后第一个月内对一名先天性长QT综合征和自发性2/1房室传导阻滞发作的患者进行了电生理学研究。这种阻滞可通过递增心房起搏重现，其下希氏带位置与心室肌本身不应期延长有关。令人惊讶的是，静脉注射心得安通过进一步延长QT间期而加重了这种现象。在霍尔特监测期间不久发生猝死，原因是2：1阻滞发作后突然恢复正常AV传导，随后立即发生室颤。
An electrophysiologic study was performed in the first month of life in a patient with the congenital long QT syndrome and spontaneous episodes of 2/1 atrioventricular block. The block could be reproduced by incremental atrial pacing, and its infrahisian location was associated with a prolongation of the refractoriness in the ventricular muscle itself Surprisingly, intravenous propranolol aggravated this phenomenon by further prolonging the QT interval. Sudden death occurred shortly thereafter during Holter monitoring and was due to a sudden resumption of normal AV conduction after an episode of 2:1 block, immediately followed by ventricular fibrillation.