Seroepidemiological study of Helicobacter pylori infection in asymptomatic people in South Korea
Seroepidemiological study of Helicobacter pylori infection in asymptomatic people in South Korea
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DOI：
10.1046/j.1440-1746.2001.02568.x
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发表时间：
2001-09-01
影响因子：
4.1
通讯作者：
Choi, KW
中科院分区：
文献类型：
--
作者：
Kim, JH;Kim, HY;Choi, KW
背景：幽门螺杆菌感染发生在世界各地，并在所有年龄组引起胃十二指肠疾病。幽门螺杆菌感染的流行程度因国家和种族而异。本研究的目的是评估韩国无症状健康人幽门螺杆菌感染的血清患病率。方法：1998年3月至1998年10月，对韩国54家医院的5732名无症状患者进行自评问卷调查。采用ELISA法测定血清幽门螺杆菌免疫球蛋白抗体水平。结果：总血清幽门螺杆菌感染阳性率为46.6%，男性（47.2%）与女性（45.9%）差异无统计学意义。在成人中，性别之间存在显著差异。从地区来看，发病率高的地区依次为江原（53.4%）、济州（52.9%）、全罗南道（50.6%）；首尔（41.9%）是发病率最低的地区。血清阳性率随年龄增长而增高，40多岁时最高（78.5%）。我们研究的特点是在10-12岁、16-19岁和20多岁三个年龄组感染率急剧上升。在首尔，被研究地区之间的患病率没有差异。结论：韩国全国幽门螺杆菌感染血清阳性率为46.6%，从发展中国家向发达国家过渡。对幽门螺杆菌感染的流行病学因素和传播途径进行更多的研究是必要的。(C) 2001 Blackwell Science Asia有限公司
Background: Helicobacter pylori infection occurs throughout the world and causes gastroduodenal diseases in all age groups. The prevalence of H. pylori infection varies between countries and races. The aim of this study was to evaluate the seroprevalence of H. pylori infection in asymptomatic healthy people in South Korea.Methods: From March 1998 to October 1998, 5732 asymptomatic subjects who responded to the self-assessment questionnaires from 54 hospitals in South Korea were enrolled in this study. The serum levels of antibodies for H. pylori immunoglobulinG were measured by using an ELISA test.Results: The overall seroprevalence of H. pylori infection was 46.6% and there was no statistical difference between males (47.2%) and females (45.9%). In adults, a significant difference was observed between genders. According to the geographic areas, the high prevalent provinces were Kangwon (53.4%), Cheju (52.9%) and Cholla province (50.6%); Seoul (41.9%) was the lowest prevalent area. The seroprevalence increased with age and was highest when patients were aged in their 40s (78.5%). The characteristic feature of our study was that the infection rate was steeply increased in three age groups (10-12 year olds, 16-19 year olds and those aged in their 20s). In Seoul, there was no difference in the prevalence rate among the districts studied.Conclusions: This nation-wide seroprevalence of H. pylori infection in South Korea was 46.6%, which showed the transition from a developing country to a developed country. More studies on the epidemiological factors and the route of transmission of H. pylori infection should be warranted. (C) 2001 Blackwell Science Asia Pty Ltd.