Effects of intratympanic gentamicin on vestibular afferents and hair cells in the chinchilla
Effects of intratympanic gentamicin on vestibular afferents and hair cells in the chinchilla
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DOI：
10.1152/jn.00160.2004
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发表时间：
2005-02-01
影响因子：
2.5
通讯作者：
Carey, JP
中科院分区：
文献类型：
--
作者：
Hirvonen, TP;Minor, LB;Carey, JP
庆大霉素对前庭毛细胞有毒性，但其对前庭传入神经的影响尚未明确。我们用庆大霉素（26.7 mg/ml）一次注入麻醉的龙猫中耳，并在5-25天（早期）或90-115天（晚期）后从传入神经进行细胞外记录。治疗后，规则，中间和不规则传入的相对比例没有变化。规则传入神经的自发放电频率较低（P
Gentamicin is toxic to vestibular hair cells, but its effects on vestibular afferents have not been defined. We treated anesthetized chinchillas with one injection of gentamicin (26.7 mg/ml) into the middle ear and made extracellular recordings from afferents after 5-25 ( early) or 90-115 days ( late). The relative proportions of regular, intermediate, and irregular afferents did not change after treatment. The spontaneous firing rate of regular afferents was lower (P