Lipid rafts: keys to sperm maturation, fertilization, and early embryogenesis.
Lipid rafts: keys to sperm maturation, fertilization, and early embryogenesis.
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DOI：
10.1155/2011/264706
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发表时间：
2011
影响因子：
5.3
通讯作者：
Yoshida M
中科院分区：
文献类型：
--
作者：
Kawano N;Yoshida K;Miyado K;Yoshida M
细胞膜由许多不同的脂质和蛋白质受体组成，它们对于调节细胞内功能和细胞信号传导是重要的。为了协调这些活动，细胞膜被分隔成稳定或瞬时形成的微区。这些隔室被称为“脂筏”。在缺乏基因转录的配子细胞中，脂质和蛋白质在这些脂筏上的分布集中在其结构和功能的变化期间，例如启动鞭毛运动和膜融合。本文介绍了脂筏在配子成熟、受精和早期胚胎发生中的作用。
Cell membranes are composed of many different lipids and protein receptors, which are important for regulating intracellular functions and cell signaling. To orchestrate these activities, the cell membrane is compartmentalized into microdomains that are stably or transiently formed. These compartments are called “lipid rafts”. In gamete cells that lack gene transcription, distribution of lipids and proteins on these lipid rafts is focused during changes in their structure and functions such as starting flagella movement and membrane fusion. In this paper, we describe the role of lipid rafts in gamete maturation, fertilization, and early embryogenesis.